EFFECTS OF ALTERED DIETARY SODIUM AND DESOXYCORTICOSTERONE ACETATE ON PLASMA PREKALLIKREIN IN RATS WITH SPECIAL REFERENCE TO HYPERTENSION
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概要
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Two series of experiments were performed to investigate the effects of altered dietary sodium, of sodium-retaining steroids, and of increased blood pressure on rat plasma prekallikrein. Plasma prekallikrein increased with age in all groups of rats; thus all comparisons are made with age-metched controls. In the NIH strain of Wistar Kyoto spontaneously hypertensive rats (SHR/N), normotensive at 4 weeks of age, a significant and sustained elevation of blood pressure was apparent by 6-8 weeks of age. Mean plasma prekallikrein, which rose with advancing age, did not differ from that of control Wistar Kyoto NIH (WKY/N) rats during the prehypertensive (0-6 weeks of age), the early hypertensive (8 weeks) or the advanced hypertensive (13 weeks) stages. In the stage of severe hypertension (19-29 weeks), however, SHR/N rats showed significantly lower plasma prekallikrein (p < 0.05-0.005) than agematched WKY/N rats. Plasma prekallikrein was higher in SHR/N in the severe-hypertension stage given a low-sodium diet than in those given an average-sodium diet (p < 0.0 1 ), and this was also the case for the age-matched WKY/N rats on a low-sodium diet, in which plasma prekallikrein was higher (p < 0.05) than in those on average-sodium diet . In young Wistar NIH (W/N) rats given average-sodium diet, desoxycorticosterone (DOC) (27.5 mg/100 gm body weight in 2 doses) increased plasma prekallikrein (p < 0.05-0.005). When DOC was given with a high-sodium diet, however, hypertension developed (p < 0.005) and plasma prekallikrein remained normal. With a low-sodium diet alone, plasma prekallikrein in W/N rats was increased by the 10th day (p < 0.05), but had returned to normal by the 30th day. Thus plasma prekallikrein increases with age and with (exogenous or endogenous) sodium-retaining steroid, and decreases with severe hypertension.
- 社団法人日本循環器学会の論文
- 1979-06-20
著者
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Yamori Yukio
Hypertension-endocrine Branch National Heart Lung And Blood Institute National Institutes Of Health
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NAKADA TERUHIRO
Hypertension-Endocrine Branch, National Heart, Lung, and Blood Institute, National Institutes of Hea
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BARTTER FREDERIC
Hypertension-Endocrine Branch, National Heart, Lung, and Blood Institute, National Institutes of Hea
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Nakada Teruhiro
Hypertension-endocrine Branch National Heart Lung And Blood Institute National Institutes Of Health
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Bartter Frederic
Hypertension-endocrine Branch National Heart Lung And Blood Institute National Institutes Of Health