CALCIUM-BINDING OF CARDIAC SARCOPLASMIC RETICULUM AND DIASTOLIC HEMODYNAMICS IN VOLUME OVERLOADED CANINE HEARTS

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概要

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• The relationship between the active Ca^<2+>-binding function of the cardiac sarcoplasmic reticulum (SR) and left ventricular (LV) relaxation was studied in various stages of chronically volume overloading canine hearts induced by complete atrio-ventricular (A-V) block. Rapid kinetic measurement of the Ca^<2+>-binding activity of SR was made using a dual-beam spectrophotometric assay procedure. LV hemodynamics, especially diastolic indexes, were evaluated by the pressure-volume relationship using a trans-epicardial echo-cardiographic technique. In this study the maximum Ca^<2+>-binding rate of SR were impaired in eccentric hypertrophied hearts and failing hearts induced by volume overload. However, there was no significant difference of SR functional defect between the hypertrophied and the failing hearts. LV systolic properties were not influenced even by chronic volume overload. Its diastolic properties, however, were reduced with the progress of eccentric hypertrophy, and were estimated to respond more sensitively to the abnormalities of cardiac function compared with systolic properties. There was a close interrelation between the Ca^<2+>-binding activity of SR on the molecular level and diastolic parameters, especially the time constant T, on the ventricular chamber level. In conclusion, the impairment of the Ca^<2+>-binding activity of SR is a cause of depression of LV diastole. However, the role of SR in the occurrence of heart failure could not be clarified in this study.

• 社団法人日本循環器学会の論文
• 1985-02-20

著者

• Maeba Takashi

  The Second Department of Surgery, Okayama University School of Medicine, Okayama

• Maeba Takashi

  The Second Department Of Surgery Okayama University Medical School

関連論文

• CALCIUM BINDING FUNCTION OF THE SARCOPLASMIC RETICULUM IN CHRONIC VOLUME OVERLOADED CANINE HEART : Myocardial metabolism . Biochemistry : 46th Annual Scientific Meeting, Japanese Circulation Society
• LEFT VENTRICULAR FUNCTION OF THE VOLUME OVERLOADED HEART CREATED BY A-V BLOCK : Heart Failure : 46th Annual Scientific Meeting, Japanese Circulation Society
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• PROTECTIVE EFFECT OF CALCIUM ANTAGONIST ON REPERFUSED MYOCARDIUM : WITH PARTICULAR REFERENCE TO SARCOPLASMIC RETICULAR FUNCTION : Cardiovascular Drugs (II) : V : 48 Annual Scientific Meeting, Japanese Circulation Society
• STUDY OF MYOCARDIAL PRESERVATION ACCORDING TO CYTOCHROME CONTENTS AND MITOCHONDRIAL FUNCTIONS. COMPARISON OF CALCIUM ANTAGONIST (VERAPAMIL) AND POTASSIUM : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Extracorpor
• CALCIUM-BINDING OF CARDIAC SARCOPLASMIC RETICULUM AND DIASTOLIC HEMODYNAMICS IN VOLUME OVERLOADED CANINE HEARTS

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