A MECHANICAL MODEL OF MITRAL INSUFFICIENCY USING CANINE PAPILLARY MUSCLE PREPARATION
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概要
- 論文の詳細を見る
A canine papillary muscle is loaded to mimic the load of the myocardium in the wall of the left ventricle with atrio-ventricular valvular insufficiency .This mechanical model which simulates the atrio-ventricular valvular regurgitation is based on two simple assumptions. The assumptions arranged for the papillary muscle experiment are as follows: 1) the force that the myocardium encounters during muscle shortening is proportional to the muscle shortening velocity due to regurgitation through a narrow regurgitant orifice; and 2) the myocardium exerts a constant force while the aortic valve is open. The muscle shortening except the isotonic phase is ascribed solely to regurgitation since the aortic valve is closed during these phases. In the combined antegrade/retrograde ejection phase, which is characterized by a constant muscle force, the shortening velocity due to regurgitation is constant because of the assumed functional relation between the muscle force and shortening velocity. The amount of shortening assigned to regurgitation in this phase is given by the duration of this phase. The present in-vitro studies offer an alternative explanation for decrease in the regurgitant fraction as total load was reduced at a constant preload. The regurgitant fraction decreased as preload was increased at a constant total load in the present study. The regurgitant fraction also decreased by either isoproterenol or CaCl_2 administration via the coronary artery.
- 社団法人日本循環器学会の論文
- 1984-03-20
著者
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Sugawara Motoaki
Department Of Medical Engineering Himeji Dokkyo University
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Sugawara Motoaki
Department Of Cardiovascular Science Tokyo Women's Medical University
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Tamiya Kouichi
Department of Surgical Science, Heart Institute Japan, Tokyo women's Medical College & Department of
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Sugawara Motoaki
Department Of Surgical Science Heart Institute Japan Tokyo Women's Medical College
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Tamiya Kouichi
Department Of Surgical Science And Cardiovascular Surgery Heart Institute Of Japan Tokyo Women'
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Tamiya Kouichi
Department Of Surgical Science Heart Institute Japan Tokyo Women's Medical College
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MILLARD RONALD
Department of Pharmacology and Cell Biophysics, University of Cincinnati, College of Medicine Cincin
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Millard Ronald
Department Of Pharmacology And Cell Biophysics University Of Cincinnati College Of Medicine Cincinna
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