INHIBITORY ACTION OF PROSTAGLANDIN E ON ANGIOTENSIN II-INDUCED ENHANCEMENT OF VASOCONSTRICTOR RESPONSE TO SYMPATHETIC NERVE STIMULATION

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概要

• 論文の詳細を見る

• The inhibitory action of prostaglandin E_1 (PGE_1) on the vasoconstrictor response to an electrical stimulation of perivascular sympathetic nerve (VSNS) was examined using the perfused central artery of an isolated rabbit ear. This response to VSNS was depressed with PGE_1 (2.0 to 5.0 ng/ml in the perfusate) and was augmented with a PG synthetase inhibitor, indomethacin (1.0μg/ml). Angiotensin II (1.0 ng/ml) enhanced the response to VSNS, whereas treatment with PGE_1 prevented the enhancing effect of angiotensin II completely. In addition, angiotensin II enhanced the response to a bolus injection of noradrenaline in an almost similar manner to that to VSNS. However, PGE_1 (2.0 to 5.0 ng/ml) did not inhibit the enhancing effect of angiotensin II on the noradrenaline response. From these results, it is suggested that there may be remarkable antagonism between PGE and the sympathetic nervous system and/or the renin-angiotensin system in the central artery of the isolated rabbit ear, and that PGE_1 probably and more potentially acts at presynaptic sites in perivascular sympathetic nerve endings than at postsynaptic ones.

• 社団法人日本循環器学会の論文
• 1983-09-20

著者

• Michibayashi Tsutomu

  Central Clinical Laboratory Sapporo Medical College

関連論文

• INHIBITORY ACTION OF PROSTAGLANDIN E ON ANGIOTENSIN II-INDUCED ENHANCEMENT OF VASOCONSTRICTOR RESPONSE TO SYMPATHETIC NERVE STIMULATION
• Relationship between endogenous prostaglandin E and the vasoconstrictor response to noradrenaline in a perfused arterial segment.

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