ALCOHOLIC CARDIOMYOPATHY : Acetaldehyde Poisoning Rat : Myocardial and Serum Enzyme Changes in Acute Exposure
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概要
- 論文の詳細を見る
In order to clarify the pathogenesis of alcoholic cardiomyopathy, acetaldehyde (Ach) was administered to rats using the inhalation method. Serum enzyme changes and structural alterations of the heart were observed at various time intervals after 2 ml of Ach exposure for 2 hours. Possible myocardium-related enzymes, such as glutamic oxaloacetic transaminase, lactic dehydrogenase and creatine phosphokinase, were elevated within 24 hours and then returned almost to the previous levels. The most significant change seen using light microscopy was a prominent contraction band scattered throughout the specimen in the groups exposed for 12 and 24 hours, respectively. Ultrastructually, mitochondrial swelling and cristal disarray concomitant with myofibrillar change (swelling of Z-band) were observed. The former was seen most prominently immediately after exposure, while the latter was observed 24 hours after exposure. The significance of these findings and the difference between alcoholic cardiomyopathy and ischemic lesions were discussed.
- 社団法人日本循環器学会の論文
- 1983-06-20
著者
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MIZOROGI Fumi
Departments of Internal Medicine Daisan Hospital, Jikei University
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FUJITA Kazuhiko
Department of Physiology, St. Marianna University School of Medicine
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Matsuda Fumio
Department Of Psychiatry And Behavioral Science School Of Medicine Tokai University
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Matsuda Fumio
Department Of Internal Medicine The Third Hospital Tokyo Jikeikai Medical College
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Mizorogi Fumi
Department Of Internal Medicine I Daisan Hospital Jikei University School Of Medicine
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Mizorogi Fumi
Department Of Internal Medicine The Third Hospital Tokyo Jikeikai Medical College
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Fujita Kazuhiko
Department Of Electronic Control Engineering Gifu National College Of Technology
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Fujita Kazuhiko
Department Of Internal Medicine The Third Hospital Tokyo Jikeikai Medical College
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TOMARU AKIHISA
Department of Internal Medicine, The Third Hospital, Tokyo Jikeikai Medical College
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NISHIYAMA NAOKI
Department of Internal Medicine, The Third Hospital, Tokyo Jikeikai Medical College
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MIURA YOSHITARO
Department of Internal Medicine, The Third Hospital, Tokyo Jikeikai Medical College
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TANAKA TERUZI
Department of Internal Medicine, The Third Hospital, Tokyo Jikeikai Medical College
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HORIGUCHI MASAHARU
Department of Internal Medicine, The Third Hospital, Tokyo Jikeikai Medical College
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Tomaru Akihisa
Department Of Internal Medicine The Third Hospital The Jikei University School Of Medicine
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Horiguchi Masaharu
Department Of Internal Medicine The Third Hospital The Jikei University School Of Medicine
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Horiguchi Masaharu
Department Of Anatomy Iwate Medical University School Of Medicine
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Tanaka Teruzi
Department Of Internal Medicine The Third Hospital Tokyo Jikeikai Medical College
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Nishiyama Naoki
Department Of Industrial Chemistry Faculty Of Technology Tokyo Metropolitan University
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Miura Yoshitaro
Department Of Internal Medicine The Third Hospital Tokyo Jikeikai Medical College
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HORIGUCHI Masaharu
Department of Adult Disease Center, the Third Hospital, Jikei University School of Medicine
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Fujita Kazuhiko
Department of Chemistry, Faculty of Science, Kobe University
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Matsuda Fumio
Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University
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