Association of Matrix Metalloproteinase Expression and Left Ventricular Function in Idiopathic Dilated Cardiomyopathy

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概要

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• Myocardial remodeling is an important predictor for the development of dilated cardiomyopathy (DCM). Matrix metallopreteinases (MMPs) are the family of proteins responsible for extracellular remodeling, and tissue inhibitors of metalloproteinases (TIMPs) tightly control their activity. In the present study, the expression of MMP-2, MMP-9, TIMP-1 and TIMP2 was determined by immunohistochemistry in right ventricular endomyocardial biopsy samples from 16 patients with idiopathic DCM, and its clinical significance was evaluated by comparison with parameters of cardiac function. To obtain a semi-quantitative assessment of MMP and TIMP expression, the average number of positive cells per high power field was counted. The left ventricular ejection fraction (LVEF) significantly correlated with the expression of both MMP-2 (r=-0.68) and TIMP-2 (r=-0.58). Patients were classified into 2 groups according to the degree of MMP-2 expression: strongly positive and weakly positive. LVEF, left ventricular (LV) end-diastolic pressure, right ventricular end-diastolic pressure, pulmonary capillary wedge pressure and the plasma norepinephrine level were significantly greater in the strongly positive group (p<0.05). I conclusion, the expression of MMPs and TIMPs in the cardiac matrix of patients with idiopathic DCM is closely associated with myocardial remodeling and subsequent deterioration of LV performance. These findings suggest new therapeutic targets for patients with idiopathic DCM.

• 社団法人日本循環器学会の論文
• 2000-04-20

著者

• YAZAKI Yoshikazu

  First Department of Internal Medicine, Shinshu University School of Medicine, Nagano, Japan.

• IMAMURA Hiroshi

  First Department of Internal Medicine, Shinshu University School of Medicine, Nagano, Japan.

• Isobe Mitsuaki

  Japanese Circulation Society Guideline Preparation Group Myocarditis

• Suzuki Jun-ichi

  First Department Of Medicine Hokkaido University School Of Medicine

• Suzuki Jun-ichi

  First Department Of Internal Medicine Shinshu University School Of Medicine

• Isobe Mitsuaki

  First Department of Internal Medicine

• Yokoseki Osamu

  First Department of Internal Medicine, Shinshu University School of Medicine

• Takenaka Hiroaki

  First Department of Surgery

• Imamura Hiroshi

  Department Of Emergency Medicine Shinshu University

• Imamura Hiroshi

  Department Of Emergency And Intensive Care Medicine Shinshu University School Of Medicine

• Isobe Mitsuaki

  First Department Of Internal Medicine Shinshu University School Of Medicine

• Takenaka Hiroaki

  Division Of Cardiology National Higashi Nagano Hospital

• Yokoseki Osamu

  First Department Of Internal Medicine Shinshu University School Of Medicine

• Yazaki Yoshikazu

  Departments Of Cardiovascular Medicine Shinshu University School Of Medicine

• Yazaki Yoshikazu

  First Department Of Internal Medicine Shinshu University School Of Medicine

• Imamura Hiroshi

  First Department Of Internal Medicine Shinshu University School Of Medicine

• Imamura Hiroshi

  Department Of Emergency And Critical Care Medicine Shinshu University School Of Medicine

• Isobe Mitsuaki

  The First Department Of Internal Medicine Shinshu University School Of Medicine

• Isobe Mitsuaki

  Department Of Cardiovascular Medicine Graduate School Of Medical And Dental Science Tokyo Medical An

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