The Effects of Antianginal Druge on Energy Expenditure During Exercise in Normal Subjects

元データ 1995-02-20 社団法人日本循環器学会

概要

The respiratory quotient (RQ=VCO_2/VO_2) provides important information (ie, the ratio of carbohydrate to fat utilization) concerning energy expenditure. We studied the effects of various antianginal drugs on energy expenditure during steady-state aerobic exercise in 9 healthy adult men. The drugs used were propranolol (a non-selective beta-blocker), metoprolol (a beta-1 selective blocker), amosulalol (an alpha- and beta blocker), nicardipine (a calcium antagonist) and isosorbide dinitrate.Each drug was administered for 2 weeks, followed by a 2-week washout period. VO_2, VCO_2 and RQ were measured with an expired gas analyzer during treadmill exercise tests before and during the administration of each drug. Two protocols of constant-load exercise were performed: Protocol 1 lasted for 10 min at a speed of 5.5 km/h and a grade of 0%, (at a level of about 30% peak VO_2), while Protocol 2 lasted for 10 min at a speed of 7 km/h and a grade of 0%, (at a level of about 40% peak VO_2). RQ during exercise was significantly increased and VO_2 was decreased after propranolol, metoprolol and amosulalol (P<0.05). Neither nicardipine nor isosorbide dinitrate produced significant changes in these values. These data suggest that propranolol, metoprolol and amosulalol increase the efficiency of energy expenditure during ordinary physical activity by increasing the utilization of carbohydrate and by decreasing the utilization of fat.

著者

Ohyanagi Mitsumasa The First Department of Internal Medicine, Hyogo College of Medicine
IWASAKI TADAAKI THE FIRST DEPARTMENT OF INTERNAL MEDICINE, HYOGO COLLEGE OF MEDICINE
Ohyanagi M Division Of Coronary Heart Disease Department Of Internal Medicine Hyogo College Of Medicine
Ohyanagi Mitsumasa The First Department Of Internal Medicine Hyogo College Of Medicine
Asakuma Susumu The First Department of Internal Medicine, Hyogo College of Medicine
Iwasaki T Department Of Internal Medicine Division Of Coronary Heart Disease Hyogo College Of Medicine
Iwasaki T 兵庫医科大学第一内科
Iwasaki Tadaaki The First Department Of Internal Medicine Hyogo College Of Medicine
Asakuma Susumu The First Department Of Internal Medicine Hyogo College Of Medicine
Iwasaki Tadaaki Department Of Internal Medicine Division Of Coronary Heart Disease Hyogo College Of Medicine
Asakuma Susumu 1st Department Of Internal Medicine Hyogo College Of Medicine
Iwasaki Tadaaki First Department Of Internal Medicine And Department Of Nuclear Medicine Hyogo College Of Medicine
Ohtsuka Misato Division Of Coronary Heart Disease Department Of Internal Medicine Hyogo College Of Medicine

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