Cytokine Inhibitors in Patients With Heart Failure and Impaired Functional Capacity
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概要
- 論文の詳細を見る
Cytokines are proteins with pleiotropic biological effects, but the pathophysiologic role of cytokine inhibitors in advanced cardiac disease remains unclear. We assessed the levels of tumor necrosis factor (TNF)-α and its soluble receptors I (sTNF-RI) and II (sTNF-RII), soluble interleukin-1 receptor antagonist (sIL-1 Ra), and interleukin-6 soluble receptor (IL-6 sR) in sera from 11 patients with severe chronic congestive heart failure (mean left ventricular ejection fraction 19±6%; mean symptom-limited oxygen consumption 13±4 ml/min per kg) and 11 healthy volunteers. The serum concentrations of TNF, sTNF-RI, and sIL-1 Ra, but not of sTNF-RII and IL-6 sR, were significantly increased in heart failure patients. Importantly, their symptom-limited oxygen consumption was strongly associated with both sTNF-RI (R=-0.68, p=0.04) and sIL-1 Ra (R=-0.77, p=0.01). These results suggest that cytokine inhibitors from different receptor families may be involved in functional disability, a characteristic feature in patients with severe congestive heart failure. Understanding the response of cytokine inhibitors to heart failure might have therapeutic value as interventions against cytokines become available.
- 社団法人日本循環器学会の論文
- 1997-08-20
著者
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Campbell Alison
Inserm Cjf 92-10 Hopital Arnaud De Villeneuve Centre Hospitalier Universitaire
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Missov Emile
Department of Cardiology and INSERM U-390, Hopital Arnaud de Villeneuve, Centre Hospitalier Universi
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Lebel Bernard
INSERM CJF 92-10, Hopital Arnaud de Villeneuve, Centre Hospitalier Universitaire
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Missov Emile
Department Of Cardiology And Inserm U-390 Hopital Arnaud De Villeneuve Centre Hospitalier Universita
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Lebel Bernard
Inserm Cjf 92-10 Hopital Arnaud De Villeneuve Centre Hospitalier Universitaire
関連論文
- Cytokine Inhibitors in Patients With Heart Failure and Impaired Functional Capacity
- 0938 International Session Cytokine Antagonists in Patients with End-Stage Congestive Heart Failure