Toward Molecular Strategies for Heart Disease : Past, Present, Future
スポンサーリンク
概要
- 論文の詳細を見る
The past two decades of cardiovascular biology and medicine have been based largely upon the consideration of the heart and vasculature as an integrated physiological system, a view that has resulted in major therapeutic advances. With the advent of developments in gene transfer, mouse and human genetics, genetic engineering of intact animals, and molecular and cellular technology, cardiovascular medicine is now on the threshold of a molecular therapeutic era^1. Major steps have been taken toward unraveling the molecular determinants of complex, integrative, and polygenic cardiovascular disease states, including atherogenesis, hypertension, cardiac hypertrophy and failure, congenital heart disease, and coronary restenosis following balloon angioplasty. Our improved understanding of the fundamental basis of these important cardiovascular disease processes has established a scientific foundation for diagnostic, prognostic, and therapeutic advances in the mainstream of cardiovascular medicine.
- 社団法人日本循環器学会の論文
- 1997-01-20
著者
-
Minamisawa Susumu
Department Of Life Science And Medical Bio-science Waseda University Graduate School Of Advanced Sci
-
Minamisawa Susumu
Department Of Life Science And Medical Bio-science Waseda University Advanced Science And Engineerin
-
Shimizu Mitsuyuki
Department of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine K
-
Chien Kenneth
Department Of Medicine University Of California:center For Molecular Genetics University Of Californ
-
Minamisawa Susumu
Department Of Medicine University Of California
-
Hoshijima Masahiko
Department of Medicine, University of California
-
Grace Andrew
Department of Medicine, University of California
-
Chien Kenneth
Department Of Medicine And Center For Molecular Genetics University Of California
-
Grace Andrew
Department Of Medicine University Of California:(present Address)the Jikei University School Of Medi
-
Hoshijima Masahiko
Department Of Medicine Center For Research In Biological Systems University Of California San Diego
-
Hoshijima Masahiko
Department Of Medicine University Of California
-
Shimizu Mitsuyuki
Department Of Medicine University Of California:(present Address)the Jikei University School Of Medi
関連論文
- OE-254 Overexpression of ATRAP(AT1 receptor-assosiated protein) in cardiomyocytes completely inhibits cardiac hypertrophy induced by Angiotensin(Cardiac hypertrophy, basic/clinical(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of th
- PJ-705 Usefulness of Inferior Vena Cava Filter for Prevention of Pulmonary Embolism in Patients with Deep Vein Thrombosis(Pulmonary circulation-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Phospholamban is a possible causal gene for hypertrophic cardiomyopathy
- Chronic Heart Failure Therapy via Cardiotropic rAAV Delivery of an S16E Mutant Phospholamban
- PE-063 Oxygenation Promotes Calcium-dependent Smooth Muscle Cell Migration in the Rat Ductus Arteriosus(PE011,Congenital Heart Disease (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-319 Adenylyl Cyclase Type 6, but not Type 2 and 5, Selectively Promotes cAMP-dependent Vascular Remodeling in Rat Ductus Arteriosus(OE54,Congenital Heart Disease/Kawasaki's Disease (M),Oral Presentation (English),The 73rd Annual Scientific Meeting of T
- PJ-432 Rising Oxygen Tension Promoted Smooth Muscle Cell Migration in the Rat Ductus Arteriosus(Congenital heart disease/Kawasaki's disease(02)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-158 Epac1 Promotes Intimal Cushion Formation of the Rat Ductus Arteriosus by Enhancing Smooth Muscle Cell Migration(Congenital heart disease/Kawasaki's disease-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- FRS-081 T-type Calcium Channels Regulate Oxygen-induced Vascular Contraction and Smooth Muscle Cell Migration in the Rat Ductus Arteriosus(Molecular Biology in Cardiovascular Diseases (basic), The 71st Annual Scientific Meeting of the Japanese Circulation
- 5 Vascular Injury-induced Upregulation of Epac1 Counteracts PKA, Promoting Smooth Muscle Cell Migration and Neointimal Thickening(The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-551 Adenylyl Cyclase Type 2 and 5/6 Differently Regulate Vascular Tone and Remodeling in the Rat Ductus Arteriosus(Congenital heart disease/Kawasaki's disease-2 (M) PE94,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Jap
- OJ-202 The Prostaglandin E Specific-receptor EP4 Plays an Essential Role in Hyaluronan-induced Neointimal Formation in Ductus Arteriosus(Congenital heart disease/Kawasaki's disease-1 (M) OJ34,Oral Presentation (Japanese),The 70th Anniversary Annual Scient
- A Novel Alternatively Spliced Variant of the Voltage-dependent Calcium Channel α 1C Isoform in the Rat Vascular and Airway Smooth Muscles (Vascular Smooth Muscle 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Adenylyl Cyclase Type II Stimulation Inhibited Indomethacin-induced Contraction of Vascular Smooth Muscle in the Rat Ductus Arteriosus(Congenital Heart Disease/Kawasaki's Disease 3 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Societ
- Type 5 Adenylyl Cyclase is Preferentially Coupled to β1-adrenoceptor Subtype in Cardiomyocytes(Cardiac Function, Basic/Clinical 3 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-015 Retinoic acid and thyroid hormones play an important role in the transcriptional regulation of sarcolipin(Excitation-Contraction Coupling/Ion Channel (A) : OJ3)(Oral Presentation (Japanese))
- 3 Regulation of Activity of Sarcoplasmic Reticulum Calcium ATPase in the Failing Heart(Plenary Session 5 (PL-5) (M) Calcium Handling Abnormality in Heart Failure,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- -1039-ELECTROCARDIOGRAPHIC FINDINGS OF FASCICULOVENTRICULAR CONNECTION DIAGNOSED FROM HEALTHY QV1 STUDENTS : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Toward Molecular Strategies for Heart Disease : Past, Present, Future
- IS002 Genetic Dissection of Congenital Heart Disease Phenotypes in RXRα-/-Mice
- IS045 Genetic Dissection of Complex Cardiac Function
- Pharmacological Inhibition of Cardiac Adenylyl Cyclase in an Isoform-Specific Manner
- Sarcolipin, a Novel Calcium Regulator, Is Preferentially Expressedin the Atrium and Is Downregulated in the Hypertrophic Heart
- Calcium cycling defects and cardiomyopathy
- OJ-022 Sarcalumenin Plays a Critical Role in SERCA2a Stability and Adaptation to Sustained Biomechanical Stresses in the Failing Heart(Heart failure, basic-2 (M) OJ4,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japane
- Sarcalumenin Deficiency Induced Cardiac Dysfunction in Mice(Excitation-contraction Coupling/Ion Channel 1 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-018 Left-sided Pressure Overload Down-regulated the Expression of Sarcolipin mRNA Preferentially in the Left Atrium(Excitation-Contraction Coupling/Ion Channel (A) : OJ3)(Oral Presentation (Japanese))
- Aldosterone Augments Angiotensin Converting Enzyme (ACE) Gene Expression Possibly through Nongenomic Glucocorticoid Receptor in Cultured Cardiac Fibroblasts (Heart Failure, Basic 7 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Societ
- Micro-domains and Molecular Systems that Control E-C Coupling and Sense Internal Mechanical Stresses in Cardiomyocytes(Keynote Lecture, Heart Failure, Cardiac Remodeling and Cardiomyopathy 1, The 71st Annual Scientific Meeting of the Japanese Circulation
- DNA microarray profiling identified a new role of growth hormone in vascular remodeling of rat ductus arteriosus
- Regulation of vascular tone and remodeling of the ductus arteriosus