Effect of Endothelium of Pulmonary Artery Vasoreactivity in Monocrotaline-Induced Pulmonary Hypertensive Rats
スポンサーリンク
概要
- 論文の詳細を見る
This study investigated vasoreactivity modulated by endothelium in pulmonary arteries from isolated monocrotaline (MCT)-induced pulmonary hypertensive rats. The responses to KCl, 5-hydroxytryptamine (5-HT), acetylcholine (ACh), and nitroglycerin (NTG) were studied in the pulmonary artery with and without endothelium for 3 weeks following MCT-treatment. The sensitivity of the contractile response to KCl markedly increased in the arteries with endothelium at 2 and 3 weeks after treatment, but only slightly in the arteries without endothelium. In addition, the sensitivity of the contractile response to 5-HT peaked 2 weeks after treatment in the arteries with endothelium, but at 1 week in those without endothelium. Although the removal of endothelium shifted the concentration-response curve for KCl and 5-HT to the left both in the control state and at 1 week, it did not shift the curves at 2 or 3 weeks. The relaxation responses to ACh and NTG, indicative of endothelium-dependent and-independent relaxation, respectively, as well as the content of tissue cGMP were reduced 2 weeks after treatment. These results suggest that the impairment of both the endothelium-dependent and -independent relaxation responses contributes to hyperreactivity of the pulmonary artery, and may in part contribute to the development of MCT-induced pulmonary hypertension.
- 社団法人日本循環器学会の論文
- 1996-07-20
著者
-
OGAWA YUJI
First Department of Internal Medicine, Asahikawa Medical College, Hokkaido, Japan
-
TOBISE KATSUYUKI
First Department of Internal Medicine, Asahikawa Medical College, Hokkaido, Japan
-
Ogawa Yuji
Division Of Cardiology Asahikawa Kosei Hospital
-
Morita Kazutoyo
First Department of Internal Medicine, Asahikawa Medical College Nishikagura
-
Ogawa Yuji
Department Of Cardiology Asahikawa Kosei Hospital
-
Tobise Katsuyuki
First Department Of Internal Medecine Asahikawa Medical College
-
Morita Kazutoyo
First Department Of Internal Medicine Asahikawa Medical College
-
Ogawa Yugi
First Department Of Internal Medicine Asahikawa Medical College
-
Tobise Katsuyuki
First Department Of Medicine Asahikawa Medical College
-
Ogawa Yuji
First Department Of Internal Medecine Asahikawa Medical College
-
Ogawa Yugi
First Department Of Medicine Asahikawa Medical College
関連論文
- A Case of Alternating Bundle Branch Block in Combination With Intra-Hisian Block
- A case report of isolated levocardia without intracardiac anomalies associated with sick sinus syndrome
- -1258-ALTERATIONS IN LEFT VENTRICULAR SYSTOLIC AND DIASTOLIC FUNCTION FOLLOWING ACUTE HYPOXIA : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -91-EFFECTS OF PROGRESSIVE HYPOXIA ON LEFT VENTRICULAR SYSTOLIC AND DIASTOLIC FUNCTION : Ventricular Function : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Diurnal ECG Changes Associated with Unusual Circadian Phythms of Sex Hormones in Brugada Syndrome with Atrial Flutter(Arrhythmia, Diagnosis/Pathophysiology/EPS 6 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Echocardiographical Differentiation of the Early Stage of Cardiac Amyloidosis from Hypertrophic Hearts(Echo/Doppler 14 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PE-130 Distal Protection in Reperfusion Prevents Heart Failure in Acute Myocardial Infarction(Acute myocardial infarction, clinical(diagnosis/treatment)(05)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Societ
- PE-406 Percentage Area Stenosis and Residual Plaque as the Strong Predictor of In-Stent Restenosis for Small Coronary Arteries(Restenosis after Angioplasty, Basic/Clinical 4 (IHD) : PE69)(Poster Session (English))
- Evaluating in Left Ventricular Function under Long-Term β-Blockade Therapy in Patients with Dilated Cardiomyopathy
- Percent Area Stenosis of Intravascular Ultrasound as the Best Predictor of In-Stent Restenosis
- Over 10 Years Benefits of β-Blockade Therapy in Patients with Dilated Cardiomyopathy
- Promising Spontaneous Regression of Restenosis in New-generation Stents
- Clinical Detection of Heat Shock Protein 72 Expression and Cardiac Function in Acute Myocardial Infarction
- Effects of Lisinopril and Nitrendipine on Urinary Albumin Excretion and Renal Function in Patients with Mild to Moderate Essential Hypertension
- Effect of Celiprolol on Cardiac Hypertrophy in Hypertension
- Effect of Celiprolol on Cardiac Hypertrophy in Hypertension
- -P15- CHANGES OF MYOCARDIAL METABOLISM DURING ATRIAL PACING IN PATIENTS WITH ISCHEMIC HEART DISEASE : Coronary Thrombosis : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 51th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -92- EFFECTS OF ALVEOLAR AND PERFUSION HYPOXIA ON HYPOXIC PULMONARY VASOCONSTRICTION : Pulmonary Circulation, Papillary Circulation : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 51th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -342-STUDIES ON THE SITE OF HYPOXIC PULMONARY VASOCONSTRICTION
- Mechanism of Endothelium-Dependent Vasorelaxation Evoked by Lysophosphatidylcholine
- The Role of Renal Dopamine in the Reduction of High Blood Pressure by β_1-Selective β-Blocker with Intrinsic Sympathomimetic Activity in Spontaneously Hypertensive Rats
- Comparison of 5-Hydroxytryptamine-Induced Contraction of Rat Pulmonary Artery to That of Aorta in Vitro
- WHY DOSE ACTIVE OXYGEN-INDUCED LIPID PEROXIDATION OF RAT MYOCARDIAL MEMBRANES IN AGEING,STREPTOZOTOCIN(STZ)-INDUCED DIABETES MELLITUS OR ISCHEMIA/REPERFUSION INCREASE?
- Enhancement of the Cardiac β-Adrenergic System at an Early Diabetic State in Spontaneously Diabetic Chinese Hamsters
- -0341-CHANGES OF BETA-ADRENOCEPTOR/ADENYLATE CYCLASE SYSTEM IN HYPERTROPHIC HEART FROM MONOCROTALINE-TREATED RATS
- Plasma von Willebrand Factor Activities in Vascular Parkinsonism : Comparison With Parkinson's Disease
- SITE OF HYPOXIC PULMONARY VASOCONSTRICTION IN PULSATILE PERFUSED CANINE LUNG LOBES
- TIME COURSE OF PULMONARY VASCULAR RESPONSE TO AN ACUTELY REPETITIVE PULMONARY MICROEMBOLISM IN DOGS : An Analysis Using Pulmonary Vascular Impedance
- -0567-INFLUENCE OF ISCHEMIA ON BETA-ADRENERGIC RECEPTOR/ADENYLATE CYCLASE ACTIVITY IN THE ISOLATED RAT HEART
- CHANGES IN THE PULMONARY VASCULAR INPUT IMPEDANCE IN PATIENTS WITH ATRIAL SEPTAL DEFECT AFTER SURGICAL CORRECTION
- DEVELOPMENTAL CHANGES OF THE MYOCARDIAL GUANINE NUCLEOTIDE BINDING PROTEIN : Myocardial Metabolism, Biochemistry : 53 Annual Scientific Meeting, Japanese Circulation Society
- -416-DEVELOPMENT AND SPATIAL CHANGES OF THE MYOCARDIAL BETA ADRENERGIC RECEPTORS : Myocardial Metabolism, Biochemistry : FREE COMMUNICATIONS(II) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- PULMONARY VASCULAR INPUT IMPEDANCE ANALYSIS BEFORE AND AFTER CLOSURE OF ADULT ATRIAL SEPTAL DEFECT : Congenital Heart Disease : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -147-VENTRICULAR WALL MOTION AND FUNCTION DURING RIGHT VENTRICULAR FREE WALL ISCHEMIA
- Role of endothelium in biphasic hypoxic response of the isolated pulmonary artery in the rat
- -0236-INTERACTION BETWEEN 5-HT RECEPTOR AND ALPHA-ADRENERGIC RECEPTOR IN RAT PULMONARY ARTERY AND AORTA
- ELECTROGENIC Na PUMP ACTIVITY ESTIMATED BY POTASSIUM RELAXATION IN PULMONARY ARTERIAL SMOOTH MUSCLE FROM MONOCROTALINE-TREATED RATS : Pulmonary, Peripheral, Cerebral Circulation : 53 Annual Scientific Meeting, Japanese Circulation Society
- INTRAVENTRICULAR CHANGES IN THE β-ADRENOCEPTOR-ADENYLATE CYCLASE SYSTEM OF THE RAT HEART WITH THE PROGRESS OF MONOCROTALINE-INDUCED RIGHT VENTRICULAR HYPERTROPHY
- Successful Treatment of a Patient with Nephrotic Syndome Associated with Chronic Lymphocytic Leukemia
- Effects of Long-term Oral Magnesium Treatment on Blood Pressure and Vascular Reactivity in Dahl Salt-Sensitive Rats
- Ca^-INDUCED CONTRACTRON AND HYPERREACTIVITY OF PULMONARY ARTERIAL SMOOTH MUSCLE IN MONOCROTALINE-TREATED RATS
- THE EFFECT OF ACUTE HYPOXIA ON LEFT VENTRICULAR FUNCTION WITH SPECIAL REFERENCE TO DIASTOLIC FUNCTION : An Analysis using Ultrasonic Method
- Effect of Endothelium of Pulmonary Artery Vasoreactivity in Monocrotaline-Induced Pulmonary Hypertensive Rats
- -18-RELEASE OF ADENOSINE AND LACTATE FROM THE HEART DURING ATRIAL PACING IN PATIENTS WITH ISCHEMIC HEART DISEASE
- Antioxidant Effects of Calcium Antagonists on Rat Myocardial Membrane Lipid Peroxidation
- TIME COURSE OF PULMONARY VASCULAR RESPONSE TO ACUTE PULMONARY HYPERTENSION IN MILIARY EMBOLISM : Pulmonary Circulation : 46th Annual Scientific Meeting, Japanese Circulation Society
- INFLUENCE OF ATRIAL AND VENTRICULAR PACING ON LEFT ATRIAL PRESSURE AND PULMONARY VENOUS FLOW WAVE : Ventricular function (I) : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
- REGULATION MECHANISM OF PULMONARY VASCULAR DIMENSIONS IN ACUTE EXPERIMENTAL PULMONARY EMBOLISM : Pulmonary Circulation, Hemodialysis : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- CHANGE IN PULMONARY HEMODYNAMICS BY MILIARY EMBOLIZATION. AN EXPERIMENTAL STUDY ON PULMONARY VASCULAR RESPONCES WITH EXCISED PERFUSED TWO-LUNG- LOBES MODEL : Pulmonary Circulation, Peripheral Circulation : IVth Auditorium : Proceedings of the 43rd Annual
- -245-INFLUENCES OF NIFEDIPINE ON THE PULMONARY CIRCULATORY DYNAMICS WITH SPECIAL REFERENCE TO PULMONARY HYPERTENSION DUE TO MILIARY EMBOLIZATION : Cardiovascular Drugs : PROCEEDINGS OF THE 42nd ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Association of polymorphisms in GCKR and TRIB1 with nonalcoholic fatty liver disease and metabolic syndrome traits