Calcitonin Gene-Related Peptide Inhibits Human Platelet Aggregation
スポンサーリンク
概要
- 論文の詳細を見る
Calcitonin gene-related peptide (CGRP) is a potent vasodilator in humans. CGRP receptors have also been found in various tissues other than blood vessels, such as the central nervous system, kidney, and heart. However, little is known about the effects of CGRP on human platelets. We investigated the effect of CGRP (human α type) on platelet aggregation in 21 healthy subjects (9 men and 12 women, mean age 54.6 years). CGRP inhibited platlet aggregation in vitro in 19 of the subjects (90.5%) in a dose-dependent manner with 50% inhibitory doses of 1.6 μmol/L and 1.1 μmol/L for aggregation induced by epinephirine and collagen, respectively. ^<125>I-labeled CGRP bound specifically to intact platelets. The dissociation constant (K_d) was 61.9±17.7 pmol and the maximum number of binding sites (B_<max>) was 6.4±3.9 pmol/10^9 platelets. The CGRP analogue (8-37)CGRP, but not calcitonin, inhibited the binding of ^<125I-CGRP to platelets. CGRP (5μmol/L), but not (8-37)CGRP or calcitonin, increased the platelet cyclic AMP (cAMP) concentration by 31.7±3.6%. Thus, CGRP inhibits platelet aggregation via a specific receptor and by increasing the platelet cAMP concentration. CGRP may play a role in the modulation of platelet function in humans.
- 社団法人日本循環器学会の論文
- 1996-09-20
著者
-
Yamaguchi Hiroshi
Division of Cardiology, Juntendo University
-
Ueda Seigo
Cardiovascular Adivision Toyo Metropolitan Geriatric Hospital
-
Ueda Seigo
Tokyo Metropolitan Geriatric Hospital
-
Matsushita Satoru
Cardiovascular Adivision, Toyo Metropolitan Geriatric Hospital
-
Matsumoto Yoshihisa
Division of Cardiology, Department of Internal Medicine, Juntendo University School of Medicine
-
Ueda Seigo
Division of Cardiology, Tokyo Metropolitan Geriatric Hospital
-
Matsushita Satoru
Division of Cardiology, Tokyo Metropolitan Geriatric Hospital
-
Ozawa Toshio
Division of Cardiology, Tokyo Metropolitan Geriatric Hospital
-
MATSUSITA Satoru
Tokyo Metropolitan Geriatric Hospital
-
Matsushita Satoru
Cardiovascular Adivision Toyo Metropolitan Geriatric Hospital
-
Matsumoto Yoshihisa
Division Of Cardiology Department Of Internal Medicine Juntendo University School Of Medicine
-
Ozawa Toshio
Cardiovascular Adivision Toyo Metropolitan Geriatric Hospital
-
Matsushita Satoru
3rd Dept. Of Intern. Med. Faculty Of Med. Univ. Of Tokyo:the Yokufukai Geriatric Hosp.
-
Ozawa Toshio
Division Of Cardiology Tokyo Metropolitan Geriatric Hospital
-
Yamaguchi Hiroshi
Division Of Cardiology Department Of Internal Medicine Juntendo University School Of Medicine
-
Yamaguchi Hiroshi
Division Of Cardiology Department Of Internal Medicine Juntendo Universit.y School Of Medicine
関連論文
- P377 THE EFFECT OF THE POLYMORPHISMS AT THE 5'-END OF THE APOLIPOPROTEIN A-I GENE ON LIPID METABOLISM AND CORONARY ARTERY DISEASE (CAD)
- P377 THE EFFECT OF THE POLYMORPHISMS AT THE 5'-END OF THE APOLIPOPROTEIN A-I GENE ON LIPID METABOLISM AND CORONARY ARTERY DISEASE (CAD)
- Usefulness of Intravenous Cibenzoline for the Termination of Paroxysmal Atrial Flutter and Fibrillation
- -1274-INTERRELATION BETWEEN DYNAMIC STIFFNESS AND ELASTANCE IN THE EJECTING CANINE HEART : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -106-EFFECTS OF PACING TACHYCARDIA AND ISOSORBIDE DINITERATE IN ISCHEMIC HEART DISEASE ON CARDIAC WORK EFFICIENCY EVALUATED WITH VOLUMIC CONDUCTANCE CATHETER : Ventricular Function : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETI
- HDL Promotes Platelet Nitric Oxide Production against LEL in Hyperlipidemic Patients(Atherosclerosis, Clinical 1 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PE-330 Diabetes Mellitus Promotes Platelet Reactive Oxygen Species (ROS) Production via NOS Uncoupling(Atherosclerosis, Clinical 6 (IHD) : PE56)(Poster Session (English))
- Calcitonin Gene-Related Peptide Inhibits Human Platelet Aggregation
- -0299- Expression and localization of Nucleoside diphosphate kinase(NDPK)-α and β isoforms in rat left ventricular myocardium(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- -1052-ENHANCED INTRACELLULAR Ca^ RESPONSF IN ENDOTHELIAL CELLS FROM SPONTANEOUSLY HYPERTENSIVE RAT (SHR) : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- INCREASE IN CYTOSOLIC FREE Ca^ IN SHR ENDOTHELIAL CELLS : Hypertension : 53 Annual Scientific Meeting, Japanese Circulation Society
- DECREASE IN c-AMP INDUCED CONTRACTION OF SHR ENDOTHELIAL CELL : Arteriosclerosis : 53 Annual Scientific Meeting, Japanese Circulation Society
- CGRP (HUMAN AND ANALOGUE)-INHIBITION OF HUMAN PLATELET AGGREGATION : Myocardial Metabolism, Biochemistry : 53 Annual Scientific Meeting, Japanese Circulation Society
- Suppressed prostaglandin 12 production in endothelial cells from spontaneously hypertensive (SHR) rat
- A Case of Swallowing-Induced Atrioventricular Block After Myocardial Infarction
- Diabetes Mellitus Decreases Endogenous NO Production and Increases Expression of Adhesive Molecules in Platelet of Elderly Patients
- Reduced L-arginine inhibition of platelet aggregation in elderly patients with diabetes mellitus
- PE-071 A Caution against BNP-guided Treatment for Heart Failure with Atrial Fibrillation(PE012,Heart Failure (Treatment) 1 (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-322 Impact of Acute Changes in Serum Insulin-like Growth Factor-1 on Prognosis of Acute Myocardial Infarction(Acute myocardial infarction, clinical(pathophysiology)(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese
- Prognostic Value of Nighttime Blood Pressure in the Elderly : A Prospective Study of 24-Hour Blood Pressure
- Power Spectral Analysis of Spontaneous Blood Pressure and Heart Rate Variability in Elderly Hypertensives
- -1216- OPERATIVE OUTCOME AND LONG TERM SURVIVAL OF PTCA AND CABG IN PATIENTS OVER 70 YEARS OLD(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- -164-EFFECTS OF SERUM LIPID PROFILE ON RESTENOSIS AFTER PTCA : Arteriosclerosis : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- COMPARISON OF ENZYMATIC, ANATOMIC AND ELECTROCARDIOGRAPHIC ESTIMATES OF MYOCARDIAL INFARCT SIZE IN MAN
- -286-A STUDY OF COLLATERAL FUNCTION IN CORONARY ARTERY DISEASE, USING STRESSED Tl^ CARDIAC SCINCIGRAM : ON 20 PATIENTS WITH TOTAL OR SUBTOTAL OBSTRUCTION IN LEFT ANTERIOR DESCENDING ARTERY (LAD) : Ischemic Heart Disease II : FREE COMMUNICATIONS(I) :
- -226-PROGRESSION OF CORONARY ATHEROSCLEROSIS AFTER CABG : Ischemic Heart Disease I : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- VECTORCARDIOGRAPHIC STUDY ON INCOMPLETE LEFT BUNDLE BRANCH BLOCK : AN AUTOPSY CORRELATION
- VECTORCARDIOGRAPHIC DIAGNOSIS OF COEXISTING LEFT VENTRICULAR HYPERTROPHY IN RIGHT BUNDLE BRANCH BLOCK
- DIAGNOSTIC SIGNIFICANCE OF T LOOP CHANGE IN FRANK LEAD VECTORCARDIOGRAM : Proceedings of the 34th Annual Meeting of the Japanese Circulation Society (part III)
- EFFECT OF VACUS NERVE ON THE CORONARY CIRCULATION AND MYOCARDIAL OXYGEN CONSUMPTION
- VECTORCARDIOGRAMS OF RIGHT BUNDLE BRANCH BLOCK IN ELDERLY PATIENTS : Value of Vectorcardiograms for Diagnosis of associated Left Ventricular Hypertrophy or Coronary Artery Disease
- 43. Reflex Regulation of the Coronary Circulation in Aortic Constriction and Hemorrhagic Hypotenion
- Usefulness of Vectorcardiography for Assessment of Severity of Right Ventricular Overloading in Congenital Heart Disease : II. Atrial Septal Defect of Secundum Type
- The Vectorcardiogram in Pulmonary Emphysema : Studies on Autopsy Cases
- Usefulness of Vectorcardiography for Assessment of Severity of Right Ventricular Overloading in Congenital Heart Disease : 1.Pulmonary Stenosis with Intact Ventricular Septum
- Acute Vascular Lesions in Experimental Renovascular Hypertension : On the Properties of Renal Factor : Part II
- A Persistent Hypertension due to Unilateral Renal-Artery Constriction in the Rabbit
- A CLINICOPATHOLOGIC STUDY ON VALVULAR DISEASES IN 5,000 CONSECUTIVE AUTOPSY OF THE AGED : Valvular Heart Disease : 53 Annual Scientific Meeting, Japanese Circulation Society
- -P316- A STUDY ON THE RELATIONSHIP BETWEEN AMBULATORY BLOOD PRESSURE WITH TARGET-ORGAN DAMAGE IN HYPERTENSIVE PATIENTS;WITH SPECIAL REFERENCE TO MORNING AND NIGHT BLOOD PRESSURE(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION
- -267- RESIDUAL LESIONS AFTER INTRACORONARY THROMBOLYSIS : IT'S ANGIOGRAPHIC OUTCOME : Ischemic Heart Diseases : FREE COMMUNICATIONS(II) : PROCEEDINGS OF THE 51th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- IS049 Transthoracic Doppler Echocardiographic Demonstration of Steal Phenomenon at the Intramyocardial Small Coronary Artery in Patients With Hypertrophic Cardiomyopathy
- Auto-anti-artery Antibody in TAKAYASU's Arthritis and Other Various Vascular Diseases : Part III
- The Diagnostic Value of Ventricular Premature Beats in Myocardial Infarction
- Acute Vascular Lesions Produced by Selected Non-pressor Renal Cortical Extracts. : Especially about the Cause of fibrinoid Necrosis in Goldblatt Type of Experimental Hypertension
- HEMODYNAMIC RESPONSES AND CORONARY ANGIOGRAPHIC FINDINGS DURING EXERCISEINDUCED ANGINA PECTORIS IN SEVERE ASHD PATIENTS : Coronary Circulation : 46th Annual Scientific Meeting, Japanese Circulation Society
- 11) DIAGNOSTIC CRITERIA AND ITS LIMITATION OF HYPERTROPHIC CARDIOMYOPATHY WITH GIANT NEGATIVE T WAVES (APICAL HYPERTROPHY)
- INCIDENCE AND CLINICAL SIGNIFICANCE OF MYOCARDIAL BRIDGING PHENOMENON : BASED ON ANGIOGRAPHIC EVALUATION : Ischemic heart disease : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
- CORONARY ARTERY SPASM AS A CAUSE OF ACUTE MYOCARDIAL INFARCTION : Coronary Circulation I : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- 16) TWENTY-FOUR HOUR AMBULATORY ELECTROCARDIOGRAPHIC MONITORING IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY: ANALYSIS OF VENTRICULAR ARRHYTHMIAS
- -0957-LACK OF CORRELATION BETWEEN P PULMONALE AND RIGHT ATRIAL OVERLOAD IN CHRONIC LUNG DISEASE : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -P89-A CLINICOPATHOLOGIC STUDY ON COLOR DOPPLER DETECTION OF TRICUSPID VALVE REGURGITANT FLOW SIGNAL IN THE AGED : Echocardiography, Pulsed Doppler : FREE COMMUNICATIONS(III) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION
- Studies on Baroreceptor Reflex Vasodilatation in Renal Circulation
- Acute Vascular Lesions Produced by Selected Non-pressor Rental Cortical Extracts
- -0208-INTERRELATION BETWEEN DYNAMIC STIFFNESS AND ELASTANCE IN THE ISOLATED RABBIT HEART
- -89-EFFECTS OF CHANGING HEART RATE, PULMONARY VENOUS PRESSURE AND ATRIAL COMPLIANCE ON FILLING FLOW DYNAMICS IN VENTRICULAR MODEL : Ventricular Function : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATI
- Cardiovascular Disease in the Aged : Overview of an Autopsy Series : PANEL DISCUSSION ON PROBLEMS IN THE TREATMENT OF CARDIOVASCULAR DISEASES IN THE ELDERLY : 51th Annual Scientific Session of the Japanese Circulation Society
- PE-011 Plasma Heparin Cofactor II Activity is a Predictor of Morphological Characteristics of Coronary Arteries Diffuse-Narrowing in Patients with Diabetes Mellitus(Angina pectoris, basic/clinical-2, The 71st Annual Scientific Meeting of the Japanese Circ
- Phonocardiographic and Hemodynamic Consequences of Intracardiac Tumor Movement : Right Atrial Myxoma Mimicking Pericarditis
- 54) Studies on the Nervous Control of the Renal Circulation
- CORONARY SPASM IN TWO SISTERS
- Impact of Serum Insulin-like Growth Factor-1 on Early Prognosis in Acute Myocardial Infarction
- A Study on the Effects of Nifedipine in Hypertensive Crises and Severe Hypertension
- Endomyocardial Resection for Recurrent Ventricular Tachycardia : Report of a Case
- Diagnostic Value of Vectorcardiogram in Myocardial Infarction : Diagnostic Sensitivity and Overdiagnosis
- 34) Diagnostic Importance of T Loop in Vectorcardiogram of the Aged : with Special Reference to Left Ventricular Hypertrophy
- A Vectorcardiographic Study on Mitral Stenosis
- Safety and Efficacy of Oral Flecainide Acetate in Patients with Cardiac Arrhythmias.
- Clinicopathological study on left ventricular hypertrophy in elderly hypertensive patients.
- A Case of Arrhythmogenic Right Ventricular Dysplasia with Atrial Flutter.
- Acute Myocardial Infarction Induced by Ergonovine Administration for Artificially Induced Abortion.
- A Case of Idiopathic Ventricular Fibrillation with Incomplete Right Bundle Branch Block and Persistent ST Segment Elevation.
- Idiopathic Ventricular Fibrillation Initiated by a Short-coupled Ventricular Premature Beat.
- Vascular Response to Drug-Eluting Stent With Biodegradable vs. Durable Polymer:– Optical Coherence Tomography Substudy of the NEXT –