Natural products drug discovery-success, challenge and developability perspective(Chemical & Pharmacological study)

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概要

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• The present review article summarizes a number of recent achievements of natural products research in the hope of demonstrating that natural products represent an unparalleled source of molecular diversity to drug discovery, and are complementary to other molecular sources, such as synthetic chemical collection and combinatorial libraries. However, challenges in natural product drug discovery are significant. Issues in drug development are increasingly complex, and development hurdles are high. There should be an increasing focus and effort on drug developability to ensure successful natural product drug development and reduce the attrition rate of drug candidates by enhancing the quality of discovery compounds that lack major liabilities, especially toxicity and problems in ADME.

• 和漢医薬学会の論文

著者

• Shu Yue

  Pharmaceutical Candidate Optimization Bristol-myers Squibb Pharmaceutical Research Institute

• Shu Yue-Zhong

  Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Pharmaceutical Research Institute

関連論文

• Natural products drug discovery-success, challenge and developability perspective(Chemical & Pharmacological study)

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