アブシジン酸の受容・代謝機構に関する生物有機化学的研究(奨励賞)

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概要

• 論文の詳細を見る

• Abscisic acid (ABA) is an essential mediator of plant responses to environmental stresses. The initial perception and metabolic inactivation of ABA by target cells remain obscure at the molecular level. We have designed and synthesized ABA analogues for probing the mechanism of ABA reception and metabolic inactivation. (1) The biological activities of four fused-type bicyclic ABA suggested that the active conformation of ABA is close to a half-chair with the side-chain axial. (2) The di-and tri-fluorination, methoxylation, or unsaturation of the 8'-methyl group of ABA resulted in the long-lasting bioactivity. (3) The 3'-fluorination of ABA stabilized the 8'-hydroxylated metabolite for isolation. The tautomeric isomerization of 8'-hydroxy-ABA to phaseic acid is significantly affected by pH. (4) The lead compound for the future design and development of an ideal ABA 8'-hydroxylase inhibitor was generated by investigation of the structural requirements for ABA 8'-hydroxylase inhibition and for ABA activity.

• 植物化学調節学会の論文
• 2005-10-13

著者

• 轟 泰司

  静岡大学農学部

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• アブシシン酸の受容・代謝機構に関する生物有機化学的研究(奨励賞,受賞業績)
• アブシジン酸の受容・代謝機構に関する生物有機化学的研究(奨励賞)

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