Age Dependence of Human gastrocnemius Mg^<2+> : Fitting ^<31>P-NMR Spectra Using Quantum Mechanics-Based Prior Knowledge

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The age dependence of human gastrocnemius Mg^<2+> concentration is demonstrated. To quantitate Mg^<2+> concentration, an original and accurate fitting algorithm using quantum mechanics-based prior knowledge is detailed. In a group of 28 volunteers (14 females) in the age range 5-80 years, pH, PCr/ATP and Pi/ATP values in the gastrocnemius were 7.02±0.02 pH, 4.16±0.33 and 0.13±0.02, respectively and independent of age and sex. By contrast, intracellular Mg^<2+> concentration (mM) decreased linearly(p<0.05) with age (Mg^<2+>=0.7803±0.0247-0.0027±0.0005 age). No difference was found between sexes. Form these results, it follows that care must be taken when comparing muscle Mg^<2+> data from subjects of different age. The hypothesis can be put forward that during aging insufficient intake and/or increased depletion of Mg^<2+> (e.g., intestinal hypoabsorption or urinary leakage) may affect the musculoskeletal system.
日本生理人類学会の論文