直流通電による局所的癌治療

概要

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The electrolysis by the use of direct current induces tissue necrosis around both electrodes.The tissue around the positive electrode becomes severely acidotic, the pH of which reaches 2 to 3,while, the negative electrodes produces marked alkalosis in the tissues.Experimental studies on mongrel dogs demonstrated the acute tissue necrosis of 0.1〜1.5cm in diameter, when 20 mA was employed for 60 minutes. Tissue impedance was approximately 500 ohms.As electrode materials, 90% platinum with 10% iridium was used. The diameter of platinum needle was 0.65mm. This approach was carried out in patients with skin or lymphnode malignant metastases. Electrodes were stitched into skin metastatic lesions or into metastatic lymphnodes. The use of direct current of 20 mA changed these lesions into dark gray tissue in colour. Histological examinations revealed neoplasma ghost findings without any malignancy.In ten clinical cases, two cases demonstrated CR, four cases were PR, 2 cases were NC and the rest was PD.Authors conclude this kind of treatment is promissing for the therapy of malignant neoplasma in the near future.
日本医療機器学会の論文
1985-10-01