437 Design and Manufacturing of Porous Scaffolds for Tissue Engineering Using Rapid Prototyping

概要

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This research paper addresses the issue of developing an efficient methodology to design and manufacture the complex scaffold structure of desired porosity required for Tissue Engineering applications using a novel approach based on the Fused Deposition Modelling (FDM) rapid prototyping (RP) technology. The scaffold provides a temporary biomechanical structure for cell growth and proliferation to produce the required body parts. Conventional techniques of scaffold fabrication (such as fibre bonding, solvent casting and melt molding) generate scaffolds with unpredictable pore sizes due to their limitations in flexibility and control of pore volume and distribution. Moreover, such scaffolds have poor mechanical strength and structural stability. The paper describes an FDM pre-processor for that ensures the fabrication of scaffolds of desired porosity and interconnectivity on the FDM system.
一般社団法人日本機械学会の論文