抗核抗体の血清学的研究 : その heterogeneity を中心として
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概要
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The antibody globulins are classified into three immunoglobulin types on the basis of their antigenically differing heavy chains and all three immunoglobulin classes have similar light chains in common. The present studies demonstrate that the antinuclear factors (ANF) of γ-G, γ-A, and γ-M immunoglobulin classes are found in the sera of patients with systemic lupus erythematosus (SLE) and other diseases, and that these immunoglobulins with the ANF activity include molecules of both L chain types. Twenty-seven sera from patients with SLE (20 cases), rheumatoid arthritis (3 cases), and other diseases were examined by immunofluorescence test with mouse liver cell nuclei. Rabbit antisera against human γ-G, γ-A, and γ-M globulin and against human type I and type II Bence Jones protein were used determine the heterogeniety of the ANF. In sera of patients with SLE, the ANF of γ-G class was found in all cases, the ANF of γ-A class in only two, and ten ANF of γ-M class in twelve, respectively. Therefore, the ANF in the four sera contained all three immunoglobulin classes, and the ANF in the eight sera contained γ-G and γ-M classes. Quantitative and qualitative studies on the ANF in SLE demonstrated that there were no significant correlations between clinical findings or course of illness and titer or classes of the ANF. In sera of patients with the other disease, the ANF of γ-M class was found in all cases, the ANF of γ-G class in three, and the ANF of γ-A class in only one. The author suggeted that the ANF of γ-M class was demonstrated dominantly in SLE, while the ANF of γ-M class was demonstrated in the heighest rate in the other diseases. The ANF in all sera binded complement unrelated to immunoglobulin classes.
- 日本アレルギー学会の論文
- 1966-03-30
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- 抗核抗体の血清学的研究 : その heterogeneity を中心として