溶血性貧血に関する実験的研究 : 第2編.抗ウサギ赤血球モルモット血清少量一回注射ウサギに発現する非定型抗体の免疫グロブリン型並びに非定型抗体産生有効分画について.

概要

論文の詳細を見る
Following a single intravenous injection of a small amount of anti-rabbit erythrocyte guinea pig serum as antigen, all rabbits developed in 5 to 10 days a typical hemolytic anemia with positive direct antiglobulin test. On the 10th day after injection, incomplete antibody proved to be Non-γ type in 6 out of 7 rabbits and the remaining one to be Mixed type, on the 15th day after injection, incomplete antibody proved to be Non-γ type in 11 out of 15 rabbits, thus, incomplete antibody initially proved to be Non-γ type. The immunoglobulin class of incomplete antibody appeared initially to be IgM type in 17 out of 20 rabbits, during the 30 experimental days there developed either IgM alone or IgM with IgG, mostly IgM alone showing much more continuous frequency. Following a single intravenous injection of the IgG fraction of anti-rabbit erythrocyte guinea pig serum as antigen, all rabbits developed a typical hemolytic anemia with positive direct and indirect antiglobulin tests, the immunoglobulin class of incomplete antibody in also shown initially in 4 out of 6 rabbits to be IgM type. It is strongly suggested that there exists in the IgG fraction of anti-rabbit erythrocyte guinea pig serum a powerful stimulant for the development of incomplete antibody.
日本アレルギー学会の論文
1968-11-30