脳における抗原抗体反応に関する研究 : 第2報 自己脳乳剤による実験
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概要
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In this present report, were investigated the histological changes in the brain caused by active immunization of autobrain extracts. On the experimental method, immunization in rabbits were performed with own brain suspension which were previously removed surgically, Each animals were received eight intraperitoneal injections, a three days apart, of the 5 ml. of the emulsions and were sacrificed and the histological changes of the brain were observed. The major patho-histological changes were found as follows. 1) in operative lesions, the formation of massive softening and liqefaction changes containing numerous fat granular cells. 2) at the distant brain tissue from operative part, the degeneration, atrophy of nervous cell, neuronophagia, glial proliferation, small softening and demyelinating lesions. On the contrary which left frontal lobectomies were only performed, organization were remarkably investigated and no significant changes were found. These patho-histological changes, predominantly the patenchymal tissue damage in brain were found similar to those in the previous experiment caused the reversed anaphylaxis by rabbit brain extract. (Report 1.) Based on these findings, the above mentioned histological changes with sever necrotic lesions in operative damage may be as result of allergic reaction by the auto-brain tissue, and it is suggested that the pathogenesis of encephalitis and demyelinating disease are caused by autoimmune mechanisms and its mechanisms could be exerted upon delay of organization. In addition to this experiment, was discussed about an autopsy cases of brain abscess that might be thought of similar pathogenesis with this study.
- 日本アレルギー学会の論文
- 1968-07-31
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