Experimental Studies on the Mechanism of an Incomplete Antibody Formation. : Effects of X-rays on an incomplete antibody formation in rabbits injected with antierythrocyte serum.

概要

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1) Following a single intravenous injection of a small amount (1.0ml/kg) of antirabbit erythrocyte guinea pig serum as antigen, most rabbits developed in five to ten days into a typical haemolytic anaemia with a severe hyperchromic anaemia, reticulocytosis and an increased osmotic fragility of red blood cells, resulting in positive direct and indirect antiglobulin tests. 2) Following whole body irradiation of 600 roentgens given at various period before or after injection of the antigen to rabbits, a complete antibody formation against the above mentioned heterologous antigen was markedly suppressed, but an incomplete antibody formation against autoerythrocytes was not suppressed, when irradiation was applied 24 to 48 hours before injection of the antigen. 3) In a group irradiated 72 to 96 hours after injection of the antigen, an incomplete antibody formation against autoerythrocytes was significantly suppressed, while a complete antibody production remained. 4) It was concluded that an incomplete antibody production against autoerythrocytes was quite different in mechanism from a complete antibody production against heterologous protein.
日本アレルギー学会の論文
1967-12-30