ACTH アレルギーに関する研究
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概要
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For the purpose of investigating the antigenicity of ACTH, the skin test, Prausnitz-Kustner reaction, the leukocytolysis in vitro and the sensitized hemagglutination test with ACTH were performed in the healthy persons without ACTH administration and the patients with or without ACTH administration in their past. The leukocytolysis in vitro, the sensitized heamgglutination test and Schultz-Dale reaction with ACTH were performed in the guinea pigs sensitized with ACTH. The results obtained were as follows: 1) In the skin test, the rate of positive reaction defined with more than 20 mm in the diameter of erythema appeared 20 minutes after intradermal injection of 0.02 ml of ACTH Solution containing 0.1 unit per milliliter was 51.6% in the patients administered ACTH in their past, while positive reaction was not found in healthy persons and the patients in both of. the case given no ACTH Among the patients administered ACTH in their past, the rate of positive reaction in the skin test with ACTH solution was 44.4% in those without the experience of allergic phenomenon related to ACTH, while all those, who had had an allergic reaction against ACTH, showed positive reaction in this test. 2) In the patients administered ACTH in their past, a significant correlation was observed between the reactions in ACTH skin test and histamine skin test. 3) Prausnitz-Kustner reaction and the leukocytolysis in vitro revealed negative in healthy persons and positive in 66.6% and 37.5% respectively of the patients administered ACTH in their past. No definite relationship was found between Prausnitz-Kustner reaction and the leukocytolysis in vitro in the patient with or without allergic reaction against ACTH. No difinite positive reaction in healthy persons was shown in the sensitized hemagglutination test, but it was apparently positive in the patients who had had an allergic reaction against ATCH. 4) In the guinea pigs sensitized with ACTH, the leukocytolysis in vitro showed a positive reaction in all cases with 49.7% of mean decreasing rate, and the sensitizedh emagglutination test as well as Schultz-Dale reaction gave a clear-cut positive reaction. From the results mentioned above, it was considered that ACTH had an antigenicity and hypersensitivity to ATCH was caused by the antigen-antibody reaction due to ACTH.
- 日本アレルギー学会の論文
- 1967-06-30
著者
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