腸内嫌気性芽胞菌のアレルギー的意義に関する研究
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概要
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It was already reported by our collaborators that the antihemolytic titers (ACL-θ) of the sera against the hemolysin (θ-toxin) of Clostridium perfingens (one of the normal bacterial flora) were shown to be markedly high in some patients with hepatic or renal diseases, and some definite changes could be induced in experimental animals by the sensitization of animals with Clostridium perfringens. Present author further studied on the significance of Clostridium in various diseases from the standpoint of allergy, through the researches including the isolation and identification of Clostridium from the feces of patients, and the measurement of ACL-θ of their sera. 1) The incidence of the positive cultures of Clostridium was 30%, and it was higher in the elder patients. Clostridium perfringens was found most frequently, followed by Clost. histolyticum or lentoputrescens. Positive cultures were obtained more frequently in the patients with liver or kidney diseases, especially in those with congestive liver disease, cholecystopathy, collagen diseases, chronic hepatitis, etc. 2) ACL-θ titers were found to be definitely higher in the group of the patients with hepatic or renal diseases compared to the control group. Particularly in those diseases, such as cholecystopathy, collagendiseases, acute hepatitis, congestive liver diseases, chronic hepatitis, chronic nephritis, etc. the patients with high titers of ACL-θ were found frequently. 3) Serum cholesterol or bilirubin had some influences on the titers of ACL-θ, but no definite correlation could be shown between them. 4) Titers of ACL-θ showed the tendency to decline in accordance with the improvement of the disease. 5) Between clostolysin-θ, streptolysin-O, ACL-θ, and ASLO, there may be some cross-reactivities.
- 日本アレルギー学会の論文
- 1967-06-30