カキの打ち子喘息に関する臨床的研究
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概要
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For the purpose of studying the antigenicity of the sea-squirts firmly adhering to the outside of the oyster's shells in the patients with oyster-shucker's asthma, skin test, Prausnitz-Kustner reaction, conjunctival test, leukocytolysis in vitro and sensitized hemagglutination reaction were performed both in the patients with oyster-shucker's asthma and in healthy oyster-shuckers, patients with ordinary bronchial asthma and healthy persons as control with antigens extracted from Ciona intestinalis, Styela plycata, Styela clava-sea-squirts adhering to the oyster's shells in Hiroshima Bay-and Halocynthia roretzi-a sea-squirt caught in Miyako Bay-and, moreover, the detection of blocking antibody as well as the observation in changes in the reactions above mentioned were attempted in the patients with oyster-shucker's asthma under the specific hyposensitization treatment. Results obtained were as follows: 1) The incidence of positive reaction in skin test or conjunctival test with sea-squirt antigens was remarkably high in the patients with oyster-shucker's asthma as compared with that of the control. In these patients the antibody of reagin type was revealed by Prausnitz-Kustner reaction and antibodies responded to leukocytolysis in vitro as well as to sensitized hemagglutination reaction were also found. A significant correlation was seen between skin test and Prausnitz-Kustner reaction or conjunctival test and also between leukocytolysis in vitro and sensitized hemagglutination reaction. 2) Among Ciona intstinalis. Styela plycata, Styela clava and Halocynthia roretzi, both antigen common to the species and antigens peculiar to the species were found. 3) In the patients with oyster-shucker's asthma received the specific hyposensitization treatment with sea-squirt antigens, the blocking antibody was detected. The blocking antibody was formed not only against the antigen used in the treatment, but also against the antigens which were not used in the treatment. 4) During the hyposensitization treatment with sea-squirt antigens, the limit of positive reaction of the skin test showed a tendency to increase. The reactions in the conjunctival test became negative or weak in the majority of the cases and the leukocytolysis in vitro showed a tendency to decline its decreasrate. No definite tendency was, however, observed in the sensitized hemagglutination reaction. From the results above mentioned, it was concluded that the patients with oyster-shucker's asthma had antibodies responded to the sea-squirt antigens and, therefore, oyster-shucker's asthma was an allergic asthma developed in the oyster-shuckers who were sensitized by sea-squirts.
- 日本アレルギー学会の論文
- 1967-05-30
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