ラント病の研究 : 雑種第一代ラットによる検討

概要

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Haemotological and histological analysis was made in runted animal which was produced experimentaly by use of F_1 hybrid rat. Runting occured in 30.7% among animals studied but occurence ratio was influenced not only by combination of species but also direction of graft of immunological competent cells. Runting was easily recognized by dermatitis, conjunctivitis, weight los and diarrhoe. Survival of runted animals was inversely proportional to latent period. Adrenocortical steodri hormone was effective for toxic manifestation such as dermatitis, conjunctivitis but tended to accerate infection and immunological imcompetency of host. Anemia, Leukopenia in hematology, decrease of γ-globulin with increase of alubumin were pertinent laboratory findings. Serologicaly, direct coombs test was positive in 15.7%, γ-globulin consumption test in 45%, but no LE cell was detected in spite of repeated examination. Spleen in runted animals became enlarged up to about 1 week, then decreased in size. Thymus kept decrease through entire course. Histologicaly, atrophy of lymph follicule, decrease of Lymphocyte, increase of reticulum cells and fibrosis were prominent. Bone marrhow showed entire decrease of cellular elements and thymus was decrease of parencyhmal cells, disappearence of Hassal corpuscle with increase of phagocyte and mononuclear cells.
日本アレルギー学会の論文
1967-04-30