カキの打ち子喘息に関する実験的研究
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概要
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Oyster-shucker's asthma is found frequently among the oyster-shuckers in the districts along Hiroshima Bay. The cause of this asthma has been considered clinically not to be oysters, but to be sea-squirts adhering to the outside of the oyster's shells. In this report the etiology of oystershucker's asthma was studied experimentally by Shultz-Dale reaction, inhalation test and sensitized hemagglutination reaction in guinea pigs sensitized with sea-squirt antigen. The sea-squirts used in the experiment were Ciona intestinalis, Styela plicata and Styela clava, which were collected at the oyster shucking workroom on Hiroshima Bay, and Halocynthia roletzi caught in Miyako Bay. The results obtained were as follows. 1) Shultz-Dale reactions in the guinea pigs sensitized by intraperitoneal injection or inhalation of sea-squirt antigens were positive in four species of sea-squirt. From this fact each sea-squirt examined is thought to have an antigenicity in guinea pigs. 2) In the guinea pigs sensitized by inhalation of sea-squirt antigens the paroxysm of asthma was provocated experimentally by re-inhalation of sea-squirt antigens and the paroxysm was confirmed by characteristic changes in the respiratory curves in the guinea pigs. 3) The respective antibodies formed against the sea-squirt antigens were found by sensitized hemagglutination reaction in the sera of the guinea pigs sensitized with sea-squirt antigents. 4) Among Cina intestinalis, Styla plicata, Styla clava and Halocynthia roletzi both antigen common to the species and antigens peculiar to the species were found by Shultz-Dale reaction, inhalation test and sensitized hemagglutination reaction. 5) The tissue antibodies produced in the guinea pigs were more numerous in the lung tissue than in the intestinal tissue in those sensitized by inhalation, while in those sensitized by intraperitoneal injection they were more numerous in the intestinal tissue than in the lung tissue. From the results above mentioned it was concluded that four species of sea-squirt had an antigenicity in guinea pigs and the paroxysm of asthma could be provocated experimentally in the guinea pigs sensitized with sea-squirt antigens by re-inhalation of antigens. These facts support the theory that oyster-shucker's asthma is an inhalation asthma, which occurs in the oyster-shuckers sensitized with the scattered substances produced during the shucking of oysters.
- 日本アレルギー学会の論文
- 1966-09-30
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