インフルエンザに対する母児免疫
スポンサーリンク
概要
- 論文の詳細を見る
During the period of the recent endemy of influenza in Japan the author tried to immunize the mother under gestation positively with Influenza-Adjuvant-Vaccine in anticipating also to bestow the immunization to the fetus. 0.1 ml of Infiuenza-Adjuvant-Vaccine was injected intramuscularly in 59 cases of pregnant women in a range of beginnings of 7th to 9th gestational month. Before the vaccination the maternal blood was taken and after the vaccination, at the delivery, the maternal bloods as well as the umbilical cord blood was taken. As the control, in 33 case, also the maternal blood as well as the umbilical cord blood was taken likewise and the antibody titers for 7 strains, namely, A-Swine, A-PR8, A1, A2, B-Lee, B-Setagaya and B-Taiwan were measured by means of the agglutination inhibition test. The results obtained were as follows. 1) On an average, in 20-40% of 92 cases composed of the maternal blood taken before the vaccination and the nonvaccinated maternal blood taken at the delivery, the antibody titers were above 32 for Type A and B, particularly for B-Setagaya strain. On the other hand, the umbilical cord blood in the control group with titers above 32 was observed only in 11.9% of them. 2) In the vaccinated group, the maternal blood at the delivery had the titers above 32 in 64.8% for Type A, 93.2% for Type B and 79.0% on an average. The umbilical cord blood revealed the titers above 32 in 57.4% for Type A, 72.7% for Type B and 65.1% on an average, which showed the conspicuous elevation of the titers of the umbilical cord blood due to the maternal vaccination. 3) The antibody titers of the umbilical cord blood were changed almost in parallel with the fluctuation of the titers of the maternal blood but in general the titers were in low levels except some cases (9.6%) in which they were almost of the same levels as in the mother or higher. 4) In no case, any side effecl of the vaccination such as premature birth, intrauterine fetal death or malformations and etc. was observed. 5) The elevation of the titers does not always mean clinically the increase of the defense potential against the infection of the influenze but the increase of the titers of the umbilical cord blood is apparently significant for the increase of the defense potential against the infection.
- 日本アレルギー学会の論文
- 1966-06-30