抗コラーゲン血清が肉芽組織形成に及ぼす影響に関しての実験病理学的研究
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概要
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This experiment was undertaken to study what influence it might have upon the growth of foreign body granulation tissue developed by implatation of sponge of 3 mm^3 in the rat and rabbit's subcutaneous tissue at the back, when anti-collagen sera were given and control groupe was injected of the normal corresponding serum. To this effect we orderd three experiments to be prepared. The first experiment: 0.1ml of anti-rat collagen rabbit serum was injected locally into the implanted sponge of the rats every other days and the histological picture of foreign body granulation tissue was investigated tranitionally after 3 to 21 days. The second experiment: 4.0ml of anti-rabbit collagen duck serum was injected into the rabbit intravenously and investigating pathomorphologically in the picture of the foreign body granulation tissue in like manners of the first experiment. The third experiment: 4.0ml of immunizing rabbit collagen rabbit serum (immunologic specificity was negative) was injected intravenously into the implanted sponge of the rabbits and histological findings was investigated as similar in the first experiment. As a result of the first and second experiments we observed that when the anticollagen sera were injected, the formation of collagen fiber in the granulation were weaker and the nuclei of the fibroblasts were degenerative and had irregular form, while exsudative inflamatory changes stronger than when normal corresponding sera were injected. After 3 weeks, the granulation tissue ghowed fairly tendency to hyalinization in the control groups, but could not be yet observed such tendency in the antisera injected groups. The influence in the second experiment was much definite than in the first experiment than anti-serum was given locally. The third experiment, we observed that no findings of the pathological changes between tne experimental and control group. It is reasonable from the above to presume that anti-collagen serum has restrict on the process of the foreign body granulation.
- 日本アレルギー学会の論文
- 1964-06-30
著者
関連論文
- 62. ウサギ心臓組織を用いての同種免疫に関する実験病理(第14回日本アレルギー学会総会)
- 追加2. 生体結合組織形成に及ぼすコラーゲン血清の影響に関する実験病理(誌上発表)(第11回日本アレルギー学会総会一般演題)
- 83. 抗コラーゲン異種並びに同種血清の生体結合組織形成に及ぼす影響に就いての実験病理学的考察(第12回日本アレルギー学会総会)
- 抗コラーゲン血清が肉芽組織形成に及ぼす影響に関しての実験病理学的研究