過敏性に先行するHyposensitivityの特異性について
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概要
- 論文の詳細を見る
Chemical allergens were divided into 3 groups in accordance with chemical affinity; group A comprised ortho, meta and para nitrophennols, group B contained nitrophenol, dinitrophenol and trinitrophenol, and group C consisted of thymol, nickel sulphate and potassium bichromate. Specifity among the three chemicals of each group was detected in retation to hyposensitivity preceding hypersensitivity. Guinea pigs were give 10 daily intracutaneous injections of 0.1cc of one of the chemical allergen of an appropriate concentration, and on the 3rd or the 5th day after the last injection their sensitivity was tested with not only the same chemical but also the two other chemicals of the same group. Hyposensitivity was determined by examining skin reactions to the chemical applied intracutaneously and specific serum reactions-changes in step heights of protein wave and absorption of ultraviolet light of the serum-induced by an intravenous injection of an appropriate amount of the chemical allergen. It was found that hyposensitivity to these chemicls was exhibited on the 3rd and 5th day by a decrease of skin reactivity, by an increase of changes in absorption of ultraviolet light and by a decrease of changes in step heights of protein wave and that the 3 groups showed differences in specifity; almost no specifity was noticed in the group A but very high specifity was shown by the group C, while the specifity among the substances of the group B was not very definite.
- 日本アレルギー学会の論文
- 1962-04-30