気管支喘息における特異的減感作療法の作用機序に関する臨床的研究
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概要
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A mechanism of the hyposensitization therapy was described with special reference to blocking antibody and reagin (IgE identified by Ishizaki and et al.). A mechanism was studied on the threshold titer of the intradermal test, passive hemagglutination titer, blocking antibody titer, serum IgG and IgE levels, and response to the inhalation test in the asthmatic patients treated by injection of house dust extract. There was a significant correlation between threshold titer and PK titer in the asthmatic patients before hyposensitization therapy. Five of 11 cases, whose threshold titers were less than 1:1000 dilution, were negative in PK reaction. However, 48 cases whose threshold titers were more than 1:10000 dilution were all positive in PK reaction. In 36 of 43 cases who were positive in the intradermal test, and moreover 25 of 26 cases, whose threshold titers were more than 1:10000 dilution, an asthmatic attack was provoked by the inhalation test of house dust extract. In the patients treated for 6 to 12 months, a significant negative correlation was observed between blocking antibody titers and PK titers. And in most cases, hemagglutination titers increased within 3 to 6 months after commencement of the hyposensitization therapy, too. Blocking antibody titers and hemagglutination titers decreased within 6 months after the cessation of the therapy. Threshold titers of intradermal test increased higher in most of the patients treated for 6 or 12 months than those treated for 3 months in favourable cases, however, in most of unfavourable cases those titer showed almost no increase. The serum IgE levels of asthmatic patients showed a tendency to decrease 3 to 6 months after the commencement of treatment. Signinificantly, serum IgE levels decreased 9 month after the hyposensitization therapy.
- 日本アレルギー学会の論文
- 1973-02-28
著者
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