腸内常在菌アレルギーの研究 : Clostridium Perfringensの臓器組織との交叉反応性について
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Previous reports indicated that the antihemolytic titers (ACLθ) of the sera against the hemolysin (θ-toxin) of Clostridium perfringens showed marked high levels in some patients with hepatic or renal disorder, and some definite lesions could be induced in the liver and the kidney of the animals immunized with Clostridium perfringens. In the present work, from Todd suggesting that Streptolysin O is similar to Clostolysin θ in its biological and biochemical characters, Author studied whether there were a cross-reactivity between Clostridium perfringens and Streptococcus hemolyticus, sensitizing rabbits by bacilli individually, and studied the affinity of each bacilli with some tissues. Further it was studied the cross-reactivity of the cell components of Clostridium perfringens with hepatic or renal tissues. 1) It was conceivable that there is a cross-reactivity between Streptolysin O and Clostolysin θ. 2) In the groups immunized with Cl.perf., some lesions similar to glomerulitis and hepatitis were observed, and in the groups immunized with Streptococci, some lesions similar to glomerulitis and less lesion of heart were observed. Renal lesion of the former was more remarkable than that of the latter. In fluorescent antibody technique, the specific stainings were found at the liver and the kidney by the anticlostridium sera, and at the kidney and the heart by the antistreptococcal sera. 3) In rabbits sensitized with the supernatant of disrupted Cl.perf., it was observed the marked lesions of glomerulitis and hepatitis. It was particularly to mention that marked granulomatous lesions similar to sarcoidosis were founded in the lung. 4) It was observed that in the fluorescent antibody technique, agar gel diffusion test and sensitized hemagglutination test, the anti-sera against the supernatant of disrupted Cl.perf. reacted with the liver and the kidney.
- 日本アレルギー学会の論文
- 1969-09-30
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