Phytin-Allergy : 第2報 Phytin-Allergyの血液学的研究

概要

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It has been revealed that red cell phosphatides act as the hapten and determinant group in "Erythron-Allergy" and among the phosphatides fractions the efficient one is cephalin, especially the inositol-containing phosphatide according to the method of extraction by FOLCH in the case of brain cephalin. When the experimental allergy is performed on rabbits with the mixture of Sodium phytate, one of the derivatives of inositol, and foreign protein as the antigen, an allergic hemolytic anemia is occured. This anemia is named the "Phytin-Allergy". In this report the hematological studies on the "Phytin-Allergy" is stated. By the sensitization no hematological changes are observed, about 20 to 90 days after the sensitization the experimental rabbits are reinjected. After the reinjection an anemia is observed, and it is elucidated this anemia is of hemolytic character. No changes are observed in leukocytes and platelets. There are no remarkable differences in the anemia among groups in which as the foreign protein, human albumin, γ-globulin or ox serum are used.
一般社団法人日本アレルギー学会の論文
1960-11-01