ノルアドレナリン皮内反応に関する研究
スポンサーリンク
概要
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The skin test was carried out by measaring the extent of pale sphere as the reaction of intradermal injection of 0.01% solution of noradrenaline in 1,618 cases of healthy individuals and of patients suffering from various kinds of diseases, and discussed the relationship between the reaction and the condition of autonomic nervous system of individuals. Healthy 167 individuals who had suffered from neither allergic diseases nor disorders of autonomic nervous system in the past, were examined as controls. There was no significant distinction of sex in the test but the degree of the reaction increased as the advance of ages. As to seasonal influences on the test, there was observed only slight seasonal fructuation in the control group, while healthy persons who had the past history of allergic diseases or disorders of of autonomic nervous system, showed a marked seasonal fructuation; the reaction strong in winter, but weak in summer. Cases suffering from hypertention, organneurosis, vegetative dysharmony, climacteric disturbance, hyperthyroidism, disorders of liver or gall-bladder and tuberculosis of the lung showed stronger reaction, and patients of bronchial asthma, peptic ulcer and hypotention showed slightly stronger reaction than the reaction of the control group. Cases of painful stadium of rheumatism and eruption stage of urticaria or contact dermatitis showed weaker reaction than the controls. Among cases of neuralgia, decompensatory heart failure, malignant tumor and anemia, patients with history of allergic diseases in the past showed stronger reaction than patients without such history. Among healthy individuals, further, persons with history of allergic diseases showed stronger reaction than persons without such history. It seemed that the reaction varied with the process of the disease. In cases of organneurosis, vegetative dysharmony, climacteric disturbance, hypertention, hyperthyroidism and so on, the reaction decreased gradually following the effect of medical treatment. In cases of bronchial asthma and urticaria, the reaction decreased during the fit of asthma and course of urticaria than before or after them. Noradrenaline intradermal test showed positive correlation between the systolic or diastolic blood pressure, and negative correlation between the capillary resistance or acetylcholine insradermal test. Either stimulation of the sympathetic nerve with sympathomimetic drugs or inhibition of the parasympathetic nerve with parasympathomimetic drugs intensified the reaction. On the contrary, when the sympathetic nerve function was inhibited or parasympathetic nerve function was stimulated, the reaction was inhibited. Summarizing the results, it might be conclude than noradrenaline intradermal test shows strong reaction in sympathiocotomic persons as well as the persons whose function of the autonomic nerveis labile.
- 1960-10-01