S.enteritidis死菌免疫マウスに於ける血中抗体の研究

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概要

• 論文の詳細を見る

• Eight groups of mice were immunized by single or repeated injections of the heat killed organisms of S. enteritidis. Pooled sera were prepared by cardial puncture from five mice at weekly intervals after immunization. Serum samples were examined by Middle brook-Dubos' passive hemagglutination, conditioned hemolysis and Sindo-Utahashi's modified Coomb's test by the use of the soluble antigen fraction derived from the organism. At the same time, the bacillary agglutination was tested also following the conventional Widal test. The incomplete antibodies which are thought to participate mainly in the hemolytic reaction, were proved to be produced dominantly and earlier than the complete antibodies. The agglutinin could not be detected in serum samples obtained from mice immunized by a single injection, while the samples prepared from the groups which were immunized by repeated injections of small amount of the organism, reacted positively in the agglutination. It is considered, therefore, that the incomplete antibodies may play an important role also in immunological studies of mice in salmonellosis.

• 日本アレルギー学会の論文
• 1960-10-01

著者

• 船津 清

  東京大学伝染病研究所

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• S.enteritidis死菌免疫マウスに於ける血中抗体の研究

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