アナフィラキシー・ショックにおける迷走神経作電流の実験的研究
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概要
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Rabbits were mainly used in the experiments on vagal action current in anaphylaxis. By perfusing 5-HT or ATP into the left ventricle of the rabbit, the fall of blood-pressure bradycardia alteration were produced as same as in anaphylaxis and at the same time the increase of the amplitude and frequency of the spikes in the vagal action current were recognized. On the other hand, a remarkable increase of 5-HT and ATP was observed in the left ventricle of the rabbit in anaphylaxis. By the transecting method of the vagal branches it was clarified that the cardiac branch of the left vagus might have the major role in the development of anaphylaxis. The remarkable change of the vagal action current was observed in anaphylaxis; the intensity of it was of it over 100-200μv and and its transmission rate was 3-15 m/sec; moreover, when such a remarkable electric change was observed, shock response always developed. When the receptors of the vagus nerve were blocked, no change was observed in the vagal action current, even if anaphylaxis were developed. Anaphylactic shock did not develop when the prechiasmatic area and sympathetic zone c were destroyed and not a change of the vagal action current was observed in such a case. Destruction of the posterior hypothalamus and sympathetic zone b could not prevent the development of anaphylaxis and also the remarkable change was observed in the vagal action current. The sympathetic nerve may not play an important role in the development of anaphylaxis, nor effect any change to its action current. In conclusion, anaphylaxis may be developed as the responses through the cardiac branch of the left vagus nerve by such activators as 5-HT or ATP.
- 日本アレルギー学会の論文
- 1960-01-01