胆石症及び胆襄炎の研究 : 特に胆襄炎の発生機序に関する臨床的並びに実験的研究

概要

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Prof. S. Matsukura and co-workers have ever demonstrated that the infection by E. Coli might have a significant role in the mechanism of producing cholecystitis. The author studied serologically on the patients suffering from cholecystitis and considered that there exists allergy by the components of E. Coli in cholecystitis. So the author studied experimentally on the relation between the infection of E. Coli and the cholecystitis by allergic and Schwartzman type reaction in the dog. Cholecystitis could not be recognized in the normal dog, even if a great number of living E. Coli were injected into the gall-blader. However, the dog sensitized with horse serum or treated with the filtrate of E. Coli produced the allergic or Schwartzman type cholecystitis, when the horse serum or the filtrate of E. Coli were reinjected. Moreover the cholecystitis produced by the injection together with E. Coli into the gall-bladder were more remarkable. These facts were clearly demonstrated by the autopsy and the patho-histological changes. From the results obtained above mentioned it might be concluded that the infection by E. Coli may strengthen the producing mechanism of cholecystitis by allergic or Schwartzman reactin. Above all, the calculi were observed in the gall-bladder cases. These finding may give a important suggestion to the theory on the forming of the calculi and the mechanism of the cholecystitis.
日本アレルギー学会の論文
1960-01-01