内皮細胞はなぜ変形,配向するか : 動脈内皮細胞の形状,配向の変化と血流の関係についての計算流体力学的試論 (<小特集>バイオエンジニアリング)

概要

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The mechanism of arterial endothelial cell deformation and alignment was studied using a three-dimensional computational fluid mechanical model of the arteriolar wall with regularly arranged intraluminal undulation simulating endothelial cells. Endothelial cells were simulated using a 2D Gaussian distribution function, which had three parameters used to define the shape of the cells. They were the elongation factor, which is the correlation coefficient of the Gaussian distribution function, the height of the cells, and the cellular angle against the blood flow. The Navier-Stokes equations of the Newtonian fluid under steady flow conditions were solved using a finite volume method, and the absolute wall shear stress (WSS) at the summit of the cells was calculated. The WSS at the nuclear bulge varied in a complex manner, and the hypothesis that the endothelial cells change their shape and alignment to minimize the WSS at the nuclear bulge was presented to explain the computed results.
一般社団法人日本機械学会の論文
1994-11-25