B22-034 CAPILLARY STRUCTURED DNA DETECTION DEVICE

概要

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A new gene-detection device, we called it "DNA capillary array", was developed. This new DNA microarray device is characterized by 8 or 20 capillaries formed on the silicone rubber (polydimethylsiloxane), 0.1 mm in depth and 0.5 or 1.0 mm in width. In each capillary, 50 to 100 oligonucleotide probes can be immobilized. The capillary structure has several advantages. Multiple samples can be analyzed in an array simultaneously. Various conditions of hybridization and washing can be achieved in an array. All procedures of reaction and washing can be easily adapted to an automation system. In order to evaluate its performance, several applications of gene expression profiling, SNP (Single Nucleotide Polymorphism) detection and Nuclease protection assay were examined. In addition, a universal chip by using DNA computer technology was discussed.
2003-11-30