Effect of "In Utero" Exposure to Low Doses of Low Energy X-rays on the Postnatal Development of Mouse

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Pregnant Swiss albino mice were exposed to a single dose of 9 mGy or 50 mGy of 70 kVp X-rays on day 3. 5 (preimplantation), 6. 5 (early organogenesis) or 11. 5 (late organogenesis) of gestation. The offspring were observed for any radiation induced changes in litter size at birth and sex ratio at 4 wks of age, and postnatal mortality and growth retardation up to 6 wks of age. Irradiation at the early organogenesis stage produced an increase in the postnatal death, statistically significant in the 50 mGy group. A significant increase in the number of retarded offspring and decrease in body weight were observed in the groups exposed at the early and late organogenesis periods. The results indicate that a single exposure to low energy low dose X-rays can be harmful to the growing embryos and the type and extent of the injury will depend on the stage of development as well as the dose of radiation.