Apoptosis of Human Tumor Cells by Chemotherapeutic Anthracyclines is Enhanced by Bax Overexpression
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概要
- 論文の詳細を見る
One of the major factors for efficacy of a chmotherapeutic drug is its activity to induce apoptosis of tumor cells. Doxorubicin and daunorubicin, radiomimetic anthracycline-group drugs, have been used for chemotherapy for about 30 years. Here we established the colorectal tumor and osteosarcoma cells in which Bax expression can be induced by the treatment of isopropyl-β-D-thiogalactopyranoside, and examined the effect of the Bax overexpression on the cell death caused by these drugs. While the Bax overexpression neither affected growth nor morphology of the undamaged cells, it enhanced the cell death caused by these drugs. Increase in cellular nucleus fragmentation and DNA ladder formation indicates that the Bax-enhanced cell death is due to enhanced apoptosis of the drug-treated cells. The enhanced cell death was not observed when the cells were irradiated with X-ray or treated with other chemotherapeutic agents we examined. These results indicate that Bax may have a specific role to enhance the efficacy of chemothrapy with anthracycline-group agents.
- 日本放射線影響学会の論文
著者
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Yagi Takashi
Department of Cardiology, Keio University School
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Yagi Takashi
京都大学 医研究 放射線遺伝
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Yagi Takashi
Department Of Radiation Genetics Graduate School Of Medicine Kyoto University:division Of Radiobiolo
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Lu Yanjun
Department Of Radiation Genetics Graduate School Of Medicine Kyoto University:cancer Research Center
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Yagi Takashi
大阪府立大学先端科学研究所
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YAGI TAKASHI
Department of Bio and Geo Sciences, Graduate School of Science, Osaka City University
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