RBE-LET Relationships in Mutagenesis by Ionizing Radiation

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概要

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• The paper considers the relationship between the quality of radiation and biological lesions produced by ionizing radiation. The paper provides a brief review of the modelling of induction of strand breakage, chromosome aberration, revertant mutation in bacteria and Drosophila melanogaster. Experimental data are presented for the relative biological effectiveness of helium ions and a-particles for mutation induction and genome lethality in Escherichia coli. The paper examines the relationship between the mutational events and LET. The RBE-LET values for T4 phage, E. coli WP2 and mwh (multiple wing hair) show dependency on LET while the w^i (white-ivory) allele mutants show no dependency. INTRODUCTION The paper considers the relationship between the quality of radiation and biological lesions produced by ionizing radiation. The paper provides a brief review of the modelling of induction of strand breakage, chromosome aberration and mutation. Experimental data are presented for the relative biological effectiveness of helium ions and a-particles for mutation induction and genome lethality in Escherichia coli. The paper examines the relationship between the mutational events and LET.

• 日本放射線影響学会の論文

著者

• Munson Richard

  Mrc Radiation And Genome Stability Unit

• Nikjoo H

  Mrc Radiation And Genome Stability Unit

• Nikjoo Hooshang

  Mrc Radiation And Genome Stability Unit

• BRIDGES BRYN

  MRC Mutation Unit, University of Sussex

• Bridges Bryn

  Mrc Mutation Unit University Of Sussex

関連論文

• RBE-LET Relationships in Mutagenesis by Ionizing Radiation

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