Cytogenetic Adaptive Response of Cultured Fish Cells to Low Doses of X-rays

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概要

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• The adaptive response was examining chromosomal aberrations and micronucleus in cultured fish cells, ULF-23 (mudminnow) and CAF-31 (gold fish). When cultured fish cells were first irradiated with small doses of X-rays, they became less sensitive to subsequent exposures to high doses. The effective adaptive dose was 4.8 cGy-9.5 cGy. Adaptive doses given cells in the Gi phase were more effective than when given in the S phase. The adaptive response was maximal at 5 hours and disappeared at 10 hours after the adaptive dose. The expression of the response was inhibited by treatment with 3-aminobenzamide, as reported for mammalian cells, and with arabinofuranoside cytosine, an inhibitor of DNA polymerase alpha. Caffeine, an inhibitor of post-replicational repair, had no effect on the response.

• 日本放射線影響学会の論文

著者

• 栗原 靖之

  横浜国立大学工学部物質工学科生物工学大講座

• RIENKJKARN MATI

  Section of Experimental Cancer Chemotherapy Research Division, National Cancer Institute

• ETOH HISAMI

  横浜国立大学工学部物質工学科生物工学大講座

• Etoh H

  横浜国立大学工学部物質工学科生物工学大講座

• Rienkjkarn Mati

  Section Of Experimental Cancer Chemotherapy Research Division National Cancer Institute

• 栗原 靖之

  横浜国立大学

関連論文

• Cytogenetic Adaptive Response of Cultured Fish Cells to Low Doses of X-rays
• 11J-101 学士力の向上と高大連携を目指した大学生による実験プログラム開発の実践報告(生物教材・教育法,一般研究発表(口頭発表))

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