Alterations in Growth Factor Pathways in Multistage Carcinogenesis of Rat Tracheal Epithelial Cells

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概要

• 論文の詳細を見る

• The role of peptide growth factors in the process of multistage carcinogenesis of rat tracheal epithelial (RTE) cells was assessed by examining growth factor requirements and expression of growth factors and their receptors in normal and transformed RTE cells. Transformed RTE cell lines show decreased requirements for bovine pituitary extract, insulin and epidermal growth factor compared to primary RTE cells in culture. An autocrine role for TGF_α in transformed RTE cells is suggested by data showing TGF_α production and decreased proliferation in the presence of TGF_α antisera and TGF_α/EGF receptor kinase inhibitor. Therefore, decreased EGF requirements in transformed RTE cells could be explained by autocrine TGF_α regulation. In contrast, no evidence for an insulin/IGF-I autocrine pathway could be detected in transformed RTE cells. These data indicate that multiple alterations in growth factor pathways occur in transformed RTE cells.

• 日本放射線影響学会の論文

著者

• NETTESHEIM Paul

  Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences

• Nettesheim Paul

  Laboratory Of Pulmonary Pathobiology National Institute Of Environmental Health Science Research

• FERRIOLA PATRICE

  Laboratory of Pulmonary Pathobiology National Institute of Environmental Health Science Research

関連論文

• XENOTRANSPLANTED IN VIVO CULTURE MODEL OF MUCOUS CELL HYPERPLASIA IN RESPIRATORY EPITHELIUM INDUCED BY HUMAN NEUTROPHIL ELASTASE
• Alterations in Growth Factor Pathways in Multistage Carcinogenesis of Rat Tracheal Epithelial Cells

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