Radiation-induced Chromosome 2 Breakage and the Initiation of Murine Radiation Acute Myeloid Leukaemogenesis

概要

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Although epidemiological studies of radiation-exposed human populations continue to provide important data on radiation oncogenesis it is recognised that a knowledge of oncogenic mechanisms is essential for meaningful extrapolation of epidemiological data to the low dose region and also for the further understanding of the biological factors that influence human sensitivity to cancer induction. In vitro cellular transformation systems that seek to mimic certain aspects of the oncogenic process will continue to play an important role in fundamental studies but, at present, the majority of these lack the complexity that is inherent in the whole animal and tissue responses that moderate the multistep progression towards malignancy. Experimental animal studies on mechanisms of oncogenic initiation, whilst technically demanding, are beginning to make substantial progress. Molecular studies on rodent mammary and skin carcinogenesis following exposure to chemical agents have provided compelling evidence that codon-specific point mutations in ras proto-oncogenes are early and possibly initiating events for these neoplasms. There are also data suggesting that ras mutations are involved in early phases of murine radiation lymphomagenesis.
日本放射線影響学会の論文