Mutational DNA Base Sequence Changes in Plasmid Damaged at a Specific Region by Ultraviolet Light
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Mutational nucleotide sequence changes by ultraviolet light (UV) in the gene for Escherichia ccli cAMP receptor protein (CRP) were analyzed. Transitions were most the frequent mutations and occurred at pyrimidine-pyrimidine sequences. Most transitions were GC to AT base changes at 3' cytosine of 5'-pyrimidinecytosine-3' sequences, supporting the concept that pyrimidine(6-4)pyrimidone, Pyr(6-4)Pyo, photoproduct is a principal pre-mutagenic lesion for transition mutations induced by UV. Transversion and frameshift mutations were also found.
- 日本放射線影響学会の論文
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