Synergistic Action of Ultraviolet Radiation and Hydrogen Peroxide on Citrulline

概要

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Ultraviolet irradiation of citrulline in the presence of hydrogen peroxide formed aspartic acid, glutamic acid, glycine, α-aminobutyric acid, norvaline, arginine and two unidentified ninhydrin-reactive products. Irradiation of citrulline, both in the presence and absence of hydrogen peroxide, formed ammonia and urea. The reactions followed the first-order kinetics with increased reaction constants in the presence of hydrogen peroxide. Without UV light, hydrogen peroxide itself had no effect on citrulline. Ionizing radiation produces hydrogen peroxide in oxygenated aqueous me-dium and forms hydroxyl radicals by radiolysis of water1). Peroxide per se has been shown to be nontoxic2) whereas its products OH and other radicals are the most powerful oxygen species known in living organisms3). Thus the aqueous solution of amino acids formed a variety of products when exposed to ionizing radiation due to the presence of oxidizing species, whereas UV light was much less destructive both in terms of number and variety of degradation products4).
日本放射線影響学会の論文