Radiation-Induced Alterations in Succinate Dehydrogenase Activity in the Muscle of Pigeon

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The histochemical changes in succinate dehydrogenase were investigated in pectoralis major muscle of pigeon exposed to sub-lethal dose (400 rad) of γ-irradiation. Biochemical study was also carried out after 200, 300 and 400 rad of irradiation. In the present study the overall decrease in enzyme activity could be due to the structural and/or functional damage to mitochondria after treatment of pigeon to different sub-lethal doses of γ-irradiation. The significance of these results has been discussed with special reference to oxidative metabolism. Radiations are known to cause disturbances in the tissue metabolism. Recent advances in molecular biology have revealed that the ionizing radiations damage to DNA may result in lethal point mutations. However, Alexander et al. 1) have postulated that DNA damage is not sole criterion, reflecting the radiosensitivity of the cell, but it is cumulative effect of different mechanism operating singly or simultaneously, which contributes to overall damage, for example, mitochondrial particles and lysosomal membranes. 1, 2)
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