Oxygen Consumption in Gamma Irradiated Mouse Testes

概要

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An elevation in respiration accompanies the irradiation of mouse testes at 600 rad following a delay of two weeks. The high metabolic activity is maintained for several weeks after the initial exposure and is most probably associated with the recovery phase of the testes when spermatogonia A are repopulating the germinal epithelium. The correlation between these two events is indicative of the proliferation of cells which, while escaping death from irradiation, have sustained considerable and perhaps permanent injury which is subsequently expressed as the aberrant metabolism observed. Using the metabolic inhibitor DNP reveals little that is directly ascribable to the effects of gamma irradiation since the pattern of inhibition for each is essentially similar in control and irradiated samples. The use of ATP, on the other hand, suggests that metabolic control in regenerating testes may be highly modified. Alternative hypotheses are also discussed.
日本放射線影響学会の論文
1983-05-00