DNA Replication and Repair in Human Cells Exposed to Thermal Neutrons

概要

論文の詳細を見る
The degree of inhibition of DNA replication and the level of DNA repair synthesis induced by thermal neutron irradiation was determined in human lymphoblastoid cell lines. Dose response experiments revealed that, when compared with equivalent doses of ^<60>Co-γ-irradiation, thermal neutrons gave rise to similar levels of inhibition of DNA replication but induced relatively low levels of DNA repair synthesis. The amount of repair synthesis after exposure of cells to thermal neutrons, was about ten-fold lower than that observed after γ-radiation. Reasons for this difference are discussed in terms of the type and incidence of damage induced by thermal neutrons. Exposure of mammalian cells to γ or x-irradiation results both in a depression in the rate of DNA replication1, 2 and a dose dependent increase in DNA repair synthesis3-5. A marked decrease in DNA replication is observed at low doses (200-500 rads) which appears to be due to inhibition of initiation of replication6.
日本放射線影響学会の論文