Early Skin Shrinkage in Mice After Single and Multifractionated Gamma-ray Exposures

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Mouse legs were exposed to ^<137>Cs gamma rays with single or multiple fractions (up to 32) at various intervals of time between doses. Levels of skin shrinkage were measured 50 to 70 days after irradiation. Neither the formula of Ellis (Ellis, 1971) nor Moulder et al. (Moulder et al. , 1975) for the time-dose relationship provided a reasonable fit to the data presented in this paper for skin shrinkage on mouse legs. The results were discussed in terms of cell survival curve models. The single-dose response curve for target cells relating to the early skin shrinkage seemed to be simple exponential until 250 rads, and then downward bending on a semilogarithmic scale. A formula which enables radiotherapists to compare and contrast treatment regimens which differ in time, dose, and fractionation patterns, is of value in clinical radiotherapy and several ones have been introduced1, 2) Of these formula, use of the concept of nominal standard dose (NSD) introduced by Ellis has increased in spite of its obvious limitation. This formula is a useful approximation in radiotherapy for treatment areas not containing vital organs and within the stated limits of 4 - 30 fractions. Recently we showed that constant exponents for N and T in an isoeffect formula are not appropriate for the data on late skin contraction of mouse legs3).
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