Photoreactivity of Chlorpromazine with Native DNA in an Aqueous Solution

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概要

• 論文の詳細を見る

• Near-UV irradiation of a mixture of chlorpromazine and native DNA caused irreversible binding of the drug or its photoproduct (s) to DNA and double strand break of DNA. When the irradiation was performed in a reaction mixture with a low salt concentration, much more photobinding occurred. Accompanying these effects, the maximum hyperchromicity of DNA at a high temperature was decreased. This can be explained by either a partial denaturation or an inhibition of melting by a formation of complex between double helical DNA and a promazine polymer.

• 日本放射線影響学会の論文

著者

• 藤田 斉

  東海大学医学部分子生物学教室

• 鈴木 堅之

  東海大学医学部

• 柳沢 福子

  東海大学医学部分子生物学教室

• 遠藤 彰

  東海大学医学部分子生物学教室

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